|
 
- 积分
- 787
- 威望
- 787
- 包包
- 1075
|
Ruth Lehmann是PGC牛人一个。 http://www.nature.com/nrm/journal/v11/n1/full/nrm2815.html' n0 N8 b: u" n1 V
Review
5 u; C0 ^) r. |( `Nature Reviews Molecular Cell Biology 11, 37-49 (January 2010) | doi:10.1038/nrm28157 S5 x& k2 V6 i7 _. y1 a8 V
/ g1 X6 u7 N- u; D# @8 ?3 X0 j3 n& sMechanisms guiding primordial germ cell migration: strategies from different organisms
5 L' q. D0 K+ C, k" j7 [2 mBrian E. Richardson1 & Ruth Lehmann1
3 t/ e; n3 p$ g8 `7 l3 N" T
$ Y$ _ W% M; NAbstract
4 m/ N v O, I O" JThe regulated migration of cells is essential for development and tissue homeostasis, and aberrant cell migration can lead to an impaired immune response and the progression of cancer. Primordial germ cells (PGCs), precursors to sperm and eggs, have to migrate across the embryo to reach somatic gonadal precursors, where they carry out their function. Studies of model organisms have revealed that, despite important differences, several features of PGC migration are conserved. PGCs require an intrinsic motility programme and external guidance cues to survive and successfully migrate. Proper guidance involves both attractive and repulsive cues and is mediated by protein and lipid signalling. |
-
总评分: 威望 + 5
包包 + 10
查看全部评分
|
发表于 2010-4-8 07:34
发表于 2011-1-10 22:48
