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iPS cell publications & timeline; z; s2 \0 o" ]( r5 N- b
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- n, d* r/ R g; ?5 A, V, vShinya Yamanaka, Pluripotency and Nuclear Reprogramming, Keystone conference, 28 March 2006; www.keystonesymposia.org/Meetings/ViewPastMeetings.cfm?MeetingID=786# Z3 P* _) ^+ Y( R" w8 d5 ~
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5 B: X* |6 W# p ]4 n- U8 YShinya Yamanaka, Identification Of Factors That Generate ES-Like Pluripotent Cells From Fibroblast Culture, ISSCR meeting, Toronto, July 2006; www.abstractonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={23482185-19E3-4771-B8CF-FDBD125BAB66}&SKey={9426630B-B824-4F8F-93F7-6C940384237C}&MKey={743B38D5-9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A624}6 x2 M2 G4 u! e
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Gretchen Vogel,“Four genes confer embryonic potential”, Science 313, 27, 7 July 2006; published online 3 July 2006; doi: 10.1126/science.313.5783.277 v% L/ z$ E: T& r8 s: y7 U1 D
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Erika Check, “Simple recipe gives adult cells embryonic powers”, Nature 442, 11, 6 July 2006; published online 4 July 2006; doi: 10.1038/442011a3 V6 r! b) k J( S- Q2 s
PEER-REVIEWED PUBLICATIONS
5 |" R, E+ U/ E(Primary research literature, excluding commentaries)
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Takahashi K and Yamanaka S, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell 126, 663-676, 25 August 2006, doi: 10.1016/j.cell.2006.07.024
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7 [" a/ ~& S5 R3 K* s1 h# K! LOkita K et al., Generation of germline-competent induced pluripotent stem cells, Nature 448, 313-317, 19 July 2007; online 6 June 2007, doi: 10.1038/nature059341 R( p4 t& O! d, ?; |6 ^3 q
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- X# h9 j8 S) v/ s; g- ?( JWernig M et al., In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state, Nature 448, 318-324, 19 July 2007; published online 6 June 2007, doi: 10.1038/nature05944$ \/ K9 n9 D% r* O
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5 ^7 E/ _3 j1 O7 u6 dMaherali N et al., Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution, Cell Stem Cell 1, 55-70, July 2007; published online 6 June 2007, doi: 10.1016/j.stem.2007.05.014
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3 p( v& G& J# O9 z' YMeissner A et al., Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells, Nature Biotechnology 25, 1177-1181, October 2007; published online 27 August 2007, doi: 10.1038/nbt1335
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Blelloch R et al., Generation of induced pluripotent stem cells in the absence of drug selection, Cell Stem Cell 1, 245-247, Sept 2007, doi: 10.1016/j.stem.2007.08.0080 t8 \7 F) w v4 z4 n: F
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Takahashi K et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell 131, 861-872, 30 November 2007; published online 20 November 2007, doi: 10.1016/j.cell.2007.11.0194 n. s5 z8 |6 o
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' s9 x6 Y+ ~' O) B1 X1 HYu J et al., Induced pluripotent stem cell lines derived from human somatic cells, Science 318, 1917-1920, 21 December 2007, published online 20 November 2007, doi: 10.1126/science.1151526# Z; _0 f: W* A" o; ?/ s
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Nakagawa M et al., Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts, Nature Biotechnology 26, 101-106, January 2008, published online 30 November 2007, doi: 10.1038/nbt1374
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Hanna J et al., Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin, Science 318, 1920-1923, 21 December 2007, online 6 Dec 2007, doi: 10.1126/science.1152092" r& ~- m8 @" k2 O( o! ^3 i
FAMILY RESEARCH COUNCIL WASHINGTON, D.C. 20001 202-393-2100 www.frc.org
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1 J1 t7 b' z7 s, oPark I-H et al., Reprogramming of human somatic cells to pluripotency with defined factors, Nature 451, 141-147, 10 January 2008, published online 23 December 2007, doi: 10.1038/nature06534/ ~4 Z' @7 s. l' \
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Wernig W et al., C-Myc is dispensable for direct reprogramming of mouse fibroblasts, Cell Stem Cell 2, 10-12, 10 January 2008, published online 28 December 2007, doi: 10.1016/j.stem.2007.12.001
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4 _* ?& i! u$ u1 a' ~. ~Yamanaka S, Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors, Cell Proliferation 41 (suppl 1), 51-56, January 2008, doi: 10.1111/j.1365-2184.2008.00493.x (www3.interscience.wiley.com/journal/119410896/abstract)+ _: @8 J7 y( y( ?
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7 _# Z9 ], N% e$ Q8 R% TBrambrink T et al. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells, Cell Stem Cell 2, 151–159, 7 February 2008, online 6 February 2008, doi: 10.1016/j.stem.2008.01.004
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3 `/ k J4 m! Q5 ]0 ~$ qAoi T et al., Generation of pluripotent stem cells from adult mouse liver and stomach cells, Science 321, 699-702, corrected 1 August 2008; published online 14 February 2008, doi:10.1126/science.1154884/ t2 C: ]0 n9 M6 e
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" J( j, \. k: ?0 Y$ H( nStadtfeld M et al., Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse, Cell Stem Cell 2, 230-240, March 2008, published online 14 February 2008, doi:10.1016/j.stem.2008.02.0015 p9 @6 R a% v n( D) `
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Lowry WE et al., Generation of human induced pluripotent stem cells from dermal fibroblasts, Proc. Natl. Acad. Sci. USA 105, 2883-2888, 26 February 2008; published online 16 February 2008, doi: 10.1073/pnas.0711983105
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Wernig M et al., Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson’s disease, Proc. Natl. Acad. Sci. USA 105, 5856-5861, 15 April 2008, doi: 10.1073/pnas.0801677105
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: ? v8 U* X5 P x0 a5 l* r8 J7 S3 s/ ?Hanna J et al., Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency, Cell 133, 250-264, 18 April 2008, doi: 10.1016/j.cell.2008.03.028# u! Y9 `/ G; ~3 w) A
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# |( w5 o' ?' _; \Schenke-Layland K et al., Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages, Stem Cells 26, 1537-1546, June 2008; published online 1 May 2008, doi: 10.1634/stemcells.2008-00331 C5 A r" ?6 J& O; I; M
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Liao J et al., Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors, Cell Research 18, 600-603, May 2008, doi: 10.1038/cr.2008.51
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Stadtfeld M et al., Reprogramming of pancreatic β cells into induced pluripotent stem cells, Current Biology 18, 890-894, 24 June 2008, published online 22 May 2008, doi: 10.1016/j.cub.2008.05.010
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/ m. M3 a' L, A. }! @+ |Mikkelsen TS et al., Dissecting direct reprogramming through integrative genomic analysis, Nature 454, 49-56, 3 July 2008; published online 28 May 2008, doi: 10.1038/nature070566 c' H7 W3 P( a* k/ O
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Mali P et al. Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts, Stem Cells 26, 1998-2005, Sept 2008; published online 29 May 2008, doi:10.1634/stemcells.2008-0346* t1 P ?, ~$ j' M6 Y
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, c3 q8 c( `: _# [: P5 v; HShi Y et al., A combined chemical and genetic approach for the generation of induced pluripotent stem cells, Cell Stem Cell 2, 525-528, June 2008, doi: 10.1016/j.stem.2008.05.011
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8 g5 g% R6 s c# h& J$ LHuangfu D et al., Induction of pluripotent stem cells by defined factors in greatly improved by small-molecule compounds, Nature Biotechnology 26, 795-797, July 2008; published online 22 June 2008, doi: 10.1038/nbt1418+ p, ~% C1 y: S) w. A: o0 C0 r
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* \4 y, {/ L$ ~$ K2 UPark I-H et al. Generation of human-induced pluripotent stem cells, Nature Protocols 3, 1180-1186, July 2008; published online 26 June 2008, Corrected online 4 September 2008, doi: 10.1038/nprot.2008.922 s- v9 t- T Q# Y; `
FAMILY RESEARCH COUNCIL WASHINGTON, D.C. 20001 202-393-2100 www.frc.org( I4 n4 x- k" v4 K
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" K- R' `1 ~7 Q0 g% R& b* BKim JB et al., Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors, Nature 454, 646-650, 31 July 2008; published online 29 June 2008, doi: 10.1038/nature07061
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, d, n i: M1 L* M& ?Wernig M et al., A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types, Nature Biotechnology 26, 916-924, August 2008; published online 1 July 2008; doi: 10.1038/nbt14839 A2 @% V" s- V8 H! f1 k- l
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Duinsbergen D et al., Induced pluripotency with endogenous and inducible genes, Experimental Cell Research 314, 3255-3263, 15 October 2008, published online 9 July 2008, doi: 10.1016/j.yexcr.2008.06.024
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Narazaki G et al., Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cell, Circulation 118, 498-506, 29 July 2008, published online 14 July 2008, doi: 10.1161/CIRCULATIONAHA.108.769562
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Mauritz C et al., Generation of functional murine cardiac myocytes from induced pluripotent stem cells, Circulation 118, 507-517, 29 July 2008, published online 14 July 2008, doi: 10.1161/CIRCULATIONAHA.108.778795
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Eminli S et al., Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression, Stem Cells 26, 2467-2474, October 2008; published online 17 July 2008, doi: 10.1634/stemcells.2008-0317
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Dimos JT et al., Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons, Science 321, 1218-1221, 29 August 2008; published online 31 July 2008, doi: 10.1126/science.1158799
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: h: z$ g# X8 `& u$ EMarson A et al., Wnt signaling promotes reprogramming of somatic cells to pluripotency, Cell Stem Cell 3, 132-135, 7 August 2008, doi: 10.1016/j.stem.2008.06.019
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. E6 G# ?5 f- O u* |9 f- MPark I-H et al., Disease-specific induced pluripotent stem cells, Cell 134, 877-886, 5 Sept 2008; published online 7 August 2008, doi: 10.1016/j.cell.2008.07.041
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Tateishi K et al., Generation of insulin-secreting islet-like clusters from human skin fibroblasts, Journal of Biological Chemistry 283, 31601-31607, 14 November 2008, published online 9 Sept 2008, DOI: 10.1074/jbc.M8065972003 l2 V5 |4 y! Z
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Maherali N et al., A high-efficiency system for the generation and study of human induced pluripotent stem cells, Cell Stem Cell 3, 340-345, 11 Sept 2008, doi: 10.1016/j.stem.2008.08.003# d, \+ r, q+ ?- `1 b+ @1 B
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Hockemeyer D et al., A drug-inducible system for direct reprogramming of human somatic cells to pluripotency, Cell Stem Cell 3, 346-353, 11 Sept 2008, doi: 10.1016/j.stem.2008.08.014. {- Q/ `: G2 k4 i
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0 V# Z8 |3 G# aStadtfeld M et al., Induced pluripotent stem cells generated without viral integration, Science 322, 945-949, 7 November 2008; published online 25 Sept 2008, doi: 10.1126/science.1162494
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# w- k8 c# ?3 B" b, HQin D et al., Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors, Journal of Biological Chemistry 283, 33730-33735, 28 November 2008; published online 1 October 2008, doi: 10.1074/jbc.M806788200
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$ u4 F2 H4 v7 s4 G) ~$ COkita K et al., Generation of mouse induced pluripotent stem cells without viral vectors, Science 322, 949-953, 7 November 2008; published online 9 October 2008, doi: 10.1126/science.1164270
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Huangfu D et al., Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2, Nature Biotechnology 26, 1269-1275, published online 12 October 2008, doi: 10.1038/nbt.1502: [2 c% ^: _( d; ^
44.
* k" @3 [- p! y7 M/ cAasen T et al., Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes, Nature Biotechnology 26, 1276-1284, November 2008; published online 17 October 2008, doi:10.1038/nbt.1503
" T, M \* Z" l. f6 ~, OFAMILY RESEARCH COUNCIL WASHINGTON, D.C. 20001 202-393-2100 www.frc.org, a( B z# P0 H
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Silva J et al., Promotion of reprogramming to ground state pluripotency by signal inhibition, PLoS Biology 6(10): e253, published 21 October 2008, doi:10.1371/journal.pbio.0060253
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, v* a* I* t& sShi Y et al., Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds, Cell Stem Cell 3, 568-574, 6 November 2008, doi: 10.1016/j.stem.2008.10.004 V' s$ P: }, c% y
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/ R8 [" Q3 R0 `( aZhao Y et al., Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation, Cell Stem Cell 3, 475-479, 6 November 2008, doi: 10.1016/j.stem.2008.10.002
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Varas F et al., Fibroblast derived induced pluripotent stem cells show no common retroviral vector insertions, Stem Cells 27, 300-306, February 2009, published online November 13, 2008; doi:10.1634/stemcells.2008-0696* i/ B$ [* W: u6 @: ^+ j
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$ r, F7 N& _7 mLiu H et al., Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts, Cell Stem Cell 3, 587-590, 4 December 2008, 10.1016/j.stem.2008.10.0148 U* _3 n+ G6 ?
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9 g0 b7 B" |+ L$ r( ]0 O, xSommer CA et al., iPS Cell Generation Using a Single Lentiviral Stem Cell Cassette, Stem Cells 27, 543-549, March 2009, published online December 18, 2008, doi: 10.1634/stemcells.2008-10755 D0 x4 P: D. L# V3 l
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Ebert AD et al., Induced pluripotent stem cells from a spinal muscular atrophy patient, Nature 457, 277-280, 15 January 2009; published online 21 December 2008; doi:10.1038/nature07677 b$ ?7 p( ` V% _, f6 R! z
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Carey BW et al., Reprogramming of murine and human somatic cells using a single polycistronic vector, Proc. Natl. Acad. Sci. USA 106, 157-162, 6 January 2008, published online 24 December 2008, doi: 10.1073/pnas.0811426106
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Choi K-D et al., Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells, Stem Cells 27, 559-567, March 2009, published online 8 January 2009, doi: 10.1634/stemcells.2008-0922- f. z. e: ?( z8 l5 T
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Liao J et al., Generation of Induced Pluripotent Stem Cell Lines from Adult Rat Cells, Cell Stem Cell 4, 11-15, 9 January 2009, doi: 10.1016/j.stem.2008.11.013. k0 D9 O; l7 r
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Li W et al., Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors, Cell Stem Cell 4, 16-19, 9 January 2009, doi: 10.1016/j.stem.2008.11.014' W6 d; L i6 Y/ @" k2 `
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Feng B et al., Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb, Nature Cell Biology 11, 197-203, February 2009, published online 11 January 2009; doi: 10.1038/ncb1827 f: M/ z- q3 W6 {' _& T2 W, v
57.
: z' x7 E' G0 ~- c2 m6 F. q, X9 [Markoulaki S et al., Transgenic mice with defined combinations of drug-inducible reprogramming factors, Nature Biotechnology 27, 169-171, February 2009; published online 18 January 2009; doi:10.1038/nbt.1520
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$ u1 u0 v9 N3 Y3 ?$ uXu D et al., Phenotypic correction of murine hemophilia A using an iPS cell-based therapy, Proc. Natl. Acad. Sci. USA 106, 808-813, 20 January 2009, doi: 10.1073/pnas.0812090106( E. `" Z) g+ V& J1 `3 P, y
59.
% q1 Z/ `# T* Z& b2 g# ]Park TS et al., Derivation of Primordial Germ Cells From Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved By Co-Culture With Human Fetal Gonadal Cells, Stem Cells 27, 783-795, published online 22 January 2009, doi: 10.1002/stem.13
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Sridharan R et al., Role of the Murine Reprogramming Factors in the Induction of Pluripotency, Cell 136, 364–377, 23 January 2009, doi: 10.1016/j.cell.2009.01.001
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7 N- c0 ]: J% _Kim JB et al., Oct4-Induced Pluripotency in Adult Neural Stem Cells, Cell 136, 41l-419, 6 February 2009, doi: 10.1016/j.cell.2009.01.023
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Marion RM et al., Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells, Cell Stem Cell 4, 141-154, 6 February 2009, doi: 10.1016/j.stem.2008.12.0102 K q4 a' c- a( x2 H. V* m
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Zhang J et al., Functional cardiomyocytes derived from human induced pluripotent stem cells, Circulation Research 104, e30-e41, published online 12 February 2009, doi: 10.1161/CIRCRESAHA.108.192237
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Chang C-W et al., Polycistronic Lentiviral Vector For Hit and Run Reprogramming Of Adult Skin Fibroblasts To Induced Pluripotent Stem Cells, Stem Cells 27, 1042-1049, May 2009, published online 12 February 2009, doi: 10.1002/stem.39
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Senju S et al., Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells, Stem Cells 27, 1021-1031, May 2009, published online 13 February 2009, doi: 10.1002/stem.33
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Guo G et al., Klf4 reverts developmentally programmed restriction of ground state pluripotency, Development 136, 1063-1069, 1 April 2009, published online 18 February 2009, doi:10.1242/dev.030957
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( S! |7 O+ [9 ~Karumbayaram S et al., Directed Differentiation of Human Induced Pluripotent Stem Cells Generates Active Motor Neurons, Stem Cells 27, 806-811, April 2009, published online 23 February 2009 doi: 10.1002/stem.31
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# o! i% a) v S0 T. o1 g* _. nShao L et al., Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame, Cell Research 19, 296-306, March 2009, published online 24 February 2009,. doi: 10.1038/cr.2009.20
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. |" {3 g, x7 s" ^6 LTaura D et al., Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells, FEBS Letters 583, 1029-1033, 18 March 2009, published online 27 February 2009, doi: 10.1016/j.febslet.2009.02.031
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' O2 I( x6 Z! Q! s9 f( @7 oChambers SM et al., Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling, Nature Biotechnology 27, 275-280, March 2009; published online 1 March 2009; doi:10.1038/nbt.1529 H. o, o$ N- E) _& N1 \2 q1 m* K
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+ p" A5 @: b$ y5 n dKaji K et al., Virus-free induction of pluripotency and subsequent excision of reprogramming factors, Nature 458, 771-775, 9 April 2009, published online 1 March 2009, doi: 10.1038/nature07864/ `8 o) ^0 n8 ~9 X
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6 C+ p( r/ K3 P7 F$ {Woltjen K et al., piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells, Nature 458, 766-770, 9 April 2009, published online 1 March 2009, doi: 10.1038/nature07863
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) d4 x w: S2 {; zZhang D et al., Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells, Cell Research 19, 429-438, April 2009, published online 3 March 2009, doi: 10.1038/cr.2009.286 w0 c2 M8 y( r- n# Y4 i' u: ?; V6 y
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- H6 H1 J& |0 E! A+ T v' OSoldner F et al., Parkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors, Cell 136, 964-977, 6 March 2009, doi: 10.1016/j.cell.2009.02.0138 N; S4 {: G) t
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+ S. b+ U' I7 P% X: Q7 XLoh Y-H et al., Generation of induced pluripotent stem cells from human blood, Blood published online 18 March 2009, doi: 10.1182/blood-2009-02-204800/ @& a. O* l- e% {+ k3 g
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Yu J et al., Human induced pluripotent stem cells free of vector and transgene sequences, Science 324, 797-801, 8 May 2009, published online 26 March 2009, doi: 10.1126/science.1172482, E( `) g0 r2 J/ J# U
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; o0 P' l; M6 G! X" J/ MDeng J et al., Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming, Nature Biotechnology 27, 353-360, April 2009; published online 29 March 2009; doi:10.1038/nbt.1530. n- k( ~: G3 L [% @, D7 s e
FAMILY RESEARCH COUNCIL WASHINGTON, D.C. 20001 202-393-2100 www.frc.org
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# q4 I9 F. r( P- \Ball MP et al., Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells, Nature Biotechnology 27, 361-368, April 2009, published online 29 March 2009, doi: 10.1038/nbt.1533 i+ G' q" \8 Z0 D; x% c
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" A+ a# W L$ Y$ L# cYusa K et al., Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon, Nature Methods published online 31 March 2009, doi:10.1038/nmeth.1323
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Judson RL et al., Embryonic stem cell-specific microRNAs promote induced pluripotency, Nature Biotechnology 27, 459-461, May 2009, published online 12 April 2009, doi: 10.1038/nbt.1535
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. f: u5 b# { u( t, z) y; XHirami Y et al., Generation of retinal cells from mouse and human induced pluripotent stem cells, Neuroscience Letters 458, 126-131, 24 July 2009, published online 18 April 2009, doi: 10.1016/j.neulet.2009.04.035
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