干细胞分化中的重要调控信号通路：报道与实例

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& x- i7 L" y; I1 [7 Q  \8 n3 F( X0 G对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。! h' W; @3 I  t2 H9 [! l
1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin' W( C" W( P2 v' @2 M8 J
Wnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。0 L' A  m1 v7 k% J* r
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1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.
  b6 k: G. N3 h$ `7 ?7 l2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.
  S, h4 |+ P( i  k/ o3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.
1 h0 v8 @! m' `" B4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.
7 q$ v/ Y* g1 h4 {" N9 Y5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.# o8 S2 `5 ]" t* X# v* [, J" N& d
6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426.' t0 e, i7 H7 g2 e" v
7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.+ {  g; f$ e5 F* X9 j8 \; [
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七篇文献全文请在附件中下载。) ]) F# v" z- C, m# ^/ k
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后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。
& E+ f3 s8 X& |2 u也欢迎大家发表自己的观点，补充各个regulation pathways。

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2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：
. g* s% [+ m3 y% y: Q$ ~1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.6 ]  ~+ \# N( [. v+ k
2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.
( D; W/ B3 L6 r, F( f  T3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
" P% i: W4 a. Q- N2 Z4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.
' k$ l. j) E: d8 z9 K. Q! C5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.
2 \8 c7 W) ?" \. l) @6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.
7 {! y: L3 i, O2 n5 }) [8 w# B7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.) ]$ J& {9 a$ M# `# B" n, @
8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.
7 n7 `* {! W# {4 }: T9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.' I9 _/ j( P# Y, n
10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283., m( ?2 G: b) N! @6 f* V! H
11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.$ j$ W6 m( l2 W) w# O6 k
12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.2 C) E( O8 ?9 R
13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.
0 F$ p" ?& J: O14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.( C- D6 z9 l8 R% F( Y# @+ F3 A
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" x0 ], h- V5 D/ Q请下载附件中的14篇全文PDF1 R, w- `: w  z/ T9 z' J! b) [+ o

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欢迎大家关注、讨论细胞分化和细胞命运决定的机制。
* a: u# v. N, j2 T7 L也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！
* Z- s5 _  S/ I7 [! E9 }4 A5 Z9 R感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。