干细胞分化中的重要调控信号通路：报道与实例

kephort

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对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。1 g! K8 ^9 [" q& j
1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin
( y) s: c; f* u. WWnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。
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9 a: X2 [# F- a4 @7 u; I1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.1 P* |) I- G9 m0 T5 V
2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.4 l- y7 B, C* {6 X2 n/ n, J
3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.
. G* a  |! ?( Q/ N5 P5 `4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.; ^3 d/ Z6 U0 k. N& P% e
5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.+ T4 w# B; l$ F/ K# w6 f
6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426., K8 `1 t" X0 ]' s4 b4 y8 ^
7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.  }9 o+ N2 y  {0 D
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七篇文献全文请在附件中下载。' \2 V4 b1 s3 `& ^2 Z2 U  L

4 N6 U. E5 s2 D0 r8 v  ^& }4 a后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。6 C; U8 H% T/ _' ]5 u( v
也欢迎大家发表自己的观点，补充各个regulation pathways。

痞子的烟头

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- a9 ~9 C' _1 R+ [* R6 ]; @谢谢海洋
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海洋注：怎么谢我了？kephort 的原创呀

jiandong2001

谢谢分享

kephort

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- s" K7 V' g0 z2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：0 B1 U8 V. C, m: N5 f( u. C& T+ j
1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.0 s' r* Y3 g, d% Q  R# \9 j% H2 c/ \
2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.  i% C- Y* N8 C& w: F: j
3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
- W& ^; X8 z( h7 r/ X% i9 Z; d4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.% D; d# e- ?: I* n8 k0 z
5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.
3 \* W$ Z% [0 N8 y* p; e6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.
; `) j4 U& o9 M- q7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.# H' H9 o  Y! W1 i$ _! C  s6 w* ]
8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.
/ b3 r& ^0 c9 h9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.
, _. Y1 y3 @4 H10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
1 P$ w% c. r# W) e$ r% Z5 x( c: \11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485./ V  t4 n' J  _' g+ o: `
12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.
% H9 @# s9 K5 i- k5 g1 K! |8 V13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.( y# P7 _( _# Z6 d% N5 n
14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.
9 b, t1 f+ k' I! K也打包提供了全文。
& W9 U" ]( R$ N& v请下载附件中的14篇全文PDF
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kephort

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" r. r" [* P: n$ R- N+ d6 D欢迎大家关注、讨论细胞分化和细胞命运决定的机制。
- l; R' F9 a; b2 \5 H& v0 F也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！
4 y0 q' s3 j0 ?9 F- _8 K+ h. d感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。

show0ji3

最近也正想看看有关细胞通路的文献，谢谢您的帖子。

tspaulzhao

很好的建议，也谢谢你的分享。

lorey

谢谢分享！

Sophia

正在看信号通路方面文献，这些真是太好了，非常感谢！

dulaiyouyu

还有Notch通路。还没有像楼主一样整理多篇相关文献。呵呵。