干细胞分化中的重要调控信号通路：报道与实例

kephort

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对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。4 m6 p% a4 o$ L6 [3 U. A' ]. c' l
1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin
/ A* G7 o# p, `( l2 D8 h6 xWnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。
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1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.
. v3 ?% c0 ^/ d3 r2 J2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.1 c/ @% y0 f$ [, g% J
3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.. Q: D5 E# q! S# y8 M$ U3 l! ^- z
4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.7 N9 i7 m4 |9 ~# d$ B; E
5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.! |( Q1 ^$ K* O" i7 @
6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426.2 T- ^; m" w! G  N/ o
7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.& j, u5 y5 S0 D& w

' Y4 _$ o# {7 P& b- a3 b七篇文献全文请在附件中下载。9 t0 N: L" w7 K9 s- c

2 z# ?/ G5 t+ z! q, h9 O后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。' [7 H3 b, `) g0 a# C
也欢迎大家发表自己的观点，补充各个regulation pathways。

痞子的烟头

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7 c# d" {# z" [, H谢谢海洋
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3 ~: q+ h5 k- [5 P+ f  W, ~% J海洋注：怎么谢我了？kephort 的原创呀

jiandong2001

谢谢分享

kephort

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/ @  ~0 K* K7 j7 t2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：+ F7 h3 J  R  g0 F4 d( N
1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.
/ C$ B; A3 S  a% D: i8 h2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.  Z# t; \7 t" A3 ?6 w
3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
" c* ], q& T& E* X, r4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.
7 a3 ?1 p* S: t& S: j5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.
9 @' t1 j+ c6 F* i8 e) a6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.
0 q0 ~' \3 {# @$ N2 v( G4 l9 R7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.
6 P) J% T4 \; M5 l5 I2 }+ w8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.# O: [) p% {2 c0 M/ {6 S* _4 E
9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.
/ D- Z: g. y2 [& l0 y  q10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
) O! ~( l; w# q, g* _11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.
6 u" r8 H8 z& k/ o# g+ `' z7 r; k12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.
9 y: t( G8 i& i5 o* ?13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.
% ?' W3 ~! M, F. W6 s& `+ q14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.3 Q2 B- A# D5 N6 s8 Y' Z5 M; a* w& T, O
也打包提供了全文。
! Q: b& L* N- e请下载附件中的14篇全文PDF' W8 y6 T3 z7 W: W( T* Z

kephort

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; k( a5 [2 l6 t' o欢迎大家关注、讨论细胞分化和细胞命运决定的机制。3 }+ O* u- Z8 c! f  ^
也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！& N$ W4 A) {7 L0 R2 {8 u, S- p5 @5 R
感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。

show0ji3

最近也正想看看有关细胞通路的文献，谢谢您的帖子。

tspaulzhao

很好的建议，也谢谢你的分享。

lorey

谢谢分享！

Sophia

正在看信号通路方面文献，这些真是太好了，非常感谢！

dulaiyouyu

还有Notch通路。还没有像楼主一样整理多篇相关文献。呵呵。