cell上最新的黑色素瘤干细胞文献

hany2007

A Temporarily Distinct Subpopulation+ n: y5 U$ i( T' \; x
of Slow-Cycling Melanoma Cells
+ k* ~: L! e- d. _$ |& FIs Required for Continuous Tumor Growth
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# P3 Y! k" `" K7 MMelanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion
9 n9 N: c1 o! W2 l. _which suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.( ?: c  ]) O0 {' H: }) j- y, o1 G6 L

2014052

非常值得学习，强烈推荐，癌症干细胞如何自我维持的，这篇文章的分子机制做得很好3 @3 `5 u% l4 A4 `" W

rubyrobin

谢谢

sunny雪语

xiexielouzhu

MEMO2012

怎么下载？

yanxm920

谢谢楼主

wzx6660

thanks for sharing

kuangfangnan

thanks for you sharing

anti1988

kankan

xiaostou

感谢楼主