cell上最新的黑色素瘤干细胞文献

hany2007

A Temporarily Distinct Subpopulation. {" X# V5 a$ |% w* q
of Slow-Cycling Melanoma Cells
- h4 v- q- J) S0 S) @! gIs Required for Continuous Tumor Growth
, I0 A5 |8 _5 P) {7 Q( H5 m9 P* E
6 @2 g  e1 T5 x" sMelanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion
+ O" L: _* s9 m( _which suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.4 e* F0 v+ P& I% H  @

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