cell上最新的黑色素瘤干细胞文献

hany2007

A Temporarily Distinct Subpopulation
  j' w1 j% U- m; _of Slow-Cycling Melanoma Cells
* i; g4 b8 l. g1 d' n0 G% k, LIs Required for Continuous Tumor Growth* W/ x8 P' f+ S8 a. r, a0 _1 S
) d0 J4 ?6 f6 B: @6 Z% }+ M  h1 O
Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion
" m% v! r2 |: L6 P) nwhich suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.
6 M! m, {9 ]0 s, V

cyl98

看看。多谢呵

yolanda_sea

多谢啦

xiaostou

感谢楼主

anti1988

kankan

kuangfangnan

thanks for you sharing

wzx6660

thanks for sharing

yanxm920

谢谢楼主

MEMO2012

怎么下载？

sunny雪语

xiexielouzhu