cell上最新的黑色素瘤干细胞文献

hany2007

A Temporarily Distinct Subpopulation$ a, k: ~: @2 O. t9 M/ h# s" q5 C
of Slow-Cycling Melanoma Cells2 n) M8 u( c1 H
Is Required for Continuous Tumor Growth7 |  w( r  V$ u2 E
2 `1 k- n* n/ g+ m6 s& @) G
Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion# {5 q: D: f% G9 y% W" P
which suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.
+ }- N8 w3 S& \1 E, |9 V7 _

cyl98

看看。多谢呵

yolanda_sea

多谢啦

xiaostou

感谢楼主

anti1988

kankan

kuangfangnan

thanks for you sharing

wzx6660

thanks for sharing

yanxm920

谢谢楼主

MEMO2012

怎么下载？

sunny雪语

xiexielouzhu