癌干细胞研究进展

sciential

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李锦军，顾健人*
7 K* W+ c& B+ Y, w: I, {2 x2 @) L（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
1 q6 @7 e! N4 o5 a摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知1 c1 a+ r2 S7 u
识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病7 [3 s8 {( P7 Q9 B4 P7 O/ N
机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
4 |( j7 l% c4 n4 H( W0 L更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与$ o3 T6 ^+ p3 H! Y3 ?
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作
, T, ?$ j' M/ u5 f: Z0 p  w一综述。" n$ d& l: k8 p/ Z+ f; C
关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生
4 L  F& k: ]* A8 E: V+ p. M中图分类号：R730.21; R730.231　　文献标识码：A
5 P% L; M/ ^5 `Recent progress in research on cancer stem cells; J, N5 z$ d& W
LI Jin-Jun, GU Jian-Ren*
4 ]; g3 u0 w+ j: |8 ?8 y& A5 U4 J! ]" ^(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,
2 r* [' z3 a' jShanghai Jiaotong University, Shanghai 200032, China)
0 l2 `; d2 a3 D) G! C; ~Abstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is* q/ s8 }* V/ G. T; _
still unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of
5 i5 N8 s: h9 j0 u8 ~4 eknowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily
: I  X% U) @, g1 }characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of
2 A' f; b2 x% U& @3 S9 fnovel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the/ h# x' |6 v, i7 T: ^2 N
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
' [# b. r7 K5 o  B# _+ Drecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug1 b3 u7 V1 e) ^, T4 P4 P
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as, G  M. {: d2 s. V0 p
many problems that remained to be solved., \. O" Z) g1 e6 Z/ k+ }* D
Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis9 s2 o( H& l; b( u5 O) z

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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

thanks

passenger101

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见闻

thank you!

lanbaiping

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yfancying

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