癌干细胞研究进展

sciential

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李锦军，顾健人*  j9 N$ ~, t4 V& ~1 e" R2 M: x
（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
4 _2 ^$ G0 G) q. N摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知( }% M/ l/ b) J8 f) y
识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病. c* ]% T) d$ J0 Y1 q( n; o
机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
5 z+ ^. g& A4 k. l! [  e- c; L/ D更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与
& `) K: x. h. U+ X. T肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作/ J2 _6 Z1 ^0 m/ `
一综述。& z; `' E, t* u6 |2 e! [: O8 [
关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生
0 P: v/ }' s' B/ Y中图分类号：R730.21; R730.231　　文献标识码：A5 L/ Q+ |: i) f* @" K1 z
Recent progress in research on cancer stem cells
% E* q" S" N6 Q# A5 RLI Jin-Jun, GU Jian-Ren*" F' q  E% t, ~% \( L
(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,3 m0 a8 D- `/ m1 ~+ r3 K/ a6 q
Shanghai Jiaotong University, Shanghai 200032, China)
$ S/ u5 y. ?" i; Y+ s5 C2 I5 lAbstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is$ x2 K! c' @; Q0 \1 X0 Z- Z, ^8 V
still unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of
3 ]+ o" X' ^" l+ n$ Zknowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily, m$ u+ t+ `, ], d+ R% b0 g
characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of
, @9 `0 Q5 l* Qnovel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the
) z5 h* O* G% Y" P5 j4 `2 C6 ~4 m) dproperties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
. e( O- j, J4 p1 k. _+ _recurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug
  ]9 \% G  Y9 s6 n$ Mresistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as' Z/ P( g* g  m- b4 ~. s
many problems that remained to be solved.
$ J) f7 ^  Y6 aKey words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis1 N5 G0 T2 Z* a4 i1 v, [! t
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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

thanks

passenger101

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见闻

thank you!

lanbaiping

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yfancying

好东西