癌干细胞研究进展

sciential

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李锦军，顾健人*
* g. s& S6 V; ?2 O# K! c（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
- g2 W  s1 j: e' W+ B' H- Q5 i! i摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知6 U1 K) T7 [$ F$ E# D; V/ m" K
识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病, Z9 a+ x7 R) ^! x0 j# g
机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
- G. [0 N8 ~; o更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与( W: \1 C5 w4 G& i
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作  f' m6 f( n1 W2 R# b+ |
一综述。! u! h& q" E2 J+ C6 B/ N& F  D  S7 C
关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生
- W( R- s/ r3 s' ^中图分类号：R730.21; R730.231　　文献标识码：A
9 O# l/ C# [7 ~' N+ tRecent progress in research on cancer stem cells
/ h( {% H. b9 k6 h) J" N4 SLI Jin-Jun, GU Jian-Ren*6 n9 y. C% b  t$ P! _
(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,
3 F  A  ?. |" Y; W, Q; RShanghai Jiaotong University, Shanghai 200032, China)
, c8 P+ p& k  Z4 r$ YAbstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is
3 ?7 u, c8 X7 q) H( l+ T+ {& Tstill unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of3 g  D. Q: N' ]+ r7 @4 I2 |3 ^) {
knowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily. m; Z1 K: I# L' r$ v
characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of. V& `7 r3 ~) k0 H1 A0 X1 C
novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the
! O* ?3 a* b" s4 e' p4 {* q0 @properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
" L; x& ]' |& C+ [$ [* Drecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug$ p7 h+ g" \( r& u% i
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as
- f* N3 ]: t* gmany problems that remained to be solved.1 k& a* r* B7 @( u3 d
Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis8 f; N! \/ R/ j

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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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passenger101

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passenger101

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见闻

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lanbaiping

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yfancying

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