癌干细胞研究进展

sciential

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) E) v: ~/ G! W6 b# Z李锦军，顾健人*' e' F$ `8 a! u- D7 A4 N
（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
/ d( j2 |9 k$ r" A5 X摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知2 z; e8 b3 g  t1 c$ J3 M
识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病$ T& V7 `, T' ^9 [" @- f! G
机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我. R) Z! F% E+ A$ i; T) \
更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与
! |; f$ B+ t; e/ B: a肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作2 _) t% G2 s/ B& X) C
一综述。8 y9 b1 ~* O) U0 B6 j" U
关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生
; g. ?. m3 b' J: S% V6 z中图分类号：R730.21; R730.231　　文献标识码：A
; P+ J) l- h$ ]* Y8 ORecent progress in research on cancer stem cells6 ^& P1 R6 ^( r) l4 \2 X& ^- N
LI Jin-Jun, GU Jian-Ren*  b- ^/ L& h+ ?  s
(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,
8 g; l0 l1 M3 m; lShanghai Jiaotong University, Shanghai 200032, China)
7 ~1 O: N. h2 C* u! i, `) }Abstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is
( B+ z2 A- x7 x# L. G' A. Cstill unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of; c' N1 O0 h5 u) k' H; Q  h
knowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily6 Y& P0 K$ G. C. j3 u: _+ j$ ~1 m; N$ j
characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of! W8 b3 B. h. G  h1 H! g4 c7 A+ l
novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the- P' h& L! l' ]* H2 S
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,9 K8 N) @% X3 u9 w8 h, a! e% s
recurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug; {- V) p! o: [% g# p
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as
& f0 k  ]* o6 o* ?. o, u5 z+ Amany problems that remained to be solved.
- i2 k' |8 @8 P/ w2 @Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

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passenger101

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见闻

thank you!

lanbaiping

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yfancying

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