癌干细胞研究进展

sciential

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& k: F2 R7 p# p# h6 f/ U' s& L李锦军，顾健人*# r5 b. C1 O$ b7 n
（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）7 W1 p: U- N; }
摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知
5 g) Y6 _3 |1 b& D识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病
: a4 q/ f' m$ @* F机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
. _0 \/ N& W1 S% i更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与
7 e- ^( ~) L( a# S! x# a% e9 ^肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作
( Z1 p; z) {6 S5 V0 U* b一综述。
- q* G% g& _0 d% K! v" Q关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生* X3 X4 I# g4 J! z; j5 X" ?
中图分类号：R730.21; R730.231　　文献标识码：A
9 |: ~% y: M# W4 j) LRecent progress in research on cancer stem cells* M# h4 p5 O* ]- G6 x% U
LI Jin-Jun, GU Jian-Ren*
* X3 L  k0 E: p, g; J- U(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,
3 h# o. g4 a4 g; n/ J1 z+ H$ `7 uShanghai Jiaotong University, Shanghai 200032, China)6 u. E) q1 ], E. a
Abstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is, G; r9 ^% b7 ~" c
still unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of7 `( u! L( E& e! \
knowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily* |: I- j% @4 j( z
characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of* ^* e" Z& F9 t( z5 @3 x
novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the+ P7 l, g. |2 w5 H( M. i$ F
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
# {( ]7 v! K* t% Vrecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug. _; U* O( [8 D8 k& s$ c1 U) s
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as$ H! i/ O3 q9 U7 ~) t/ z
many problems that remained to be solved.+ I/ L5 Q( n! w# N( W( ?8 p
Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis- c5 P' S9 ?9 g

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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

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passenger101

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见闻

thank you!

lanbaiping

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yfancying

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