癌干细胞研究进展

sciential

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, X* _- o1 |4 F( l3 c李锦军，顾健人*
! I3 C+ h/ s, g0 P& n6 ]3 B7 |（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
1 s4 d( J! C0 l/ T. e摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知
- {6 |4 K5 M* {" g+ v: r2 H识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病
$ ?( T+ o  g: V% }9 _& z/ p" x, p机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我" Z7 o- X; f; Q3 ~% Q" \& H% A
更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与/ B9 Z* _5 H- h. Z4 V; m( q
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作2 W3 r8 V1 _) b; y0 e. ?
一综述。
  ~6 e/ s2 u4 I$ }5 H- A0 J关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生0 S6 }+ t8 y2 H. y) g
中图分类号：R730.21; R730.231　　文献标识码：A
8 p5 ]; r& _/ i7 zRecent progress in research on cancer stem cells
6 a1 E" s  b* s" a5 |LI Jin-Jun, GU Jian-Ren*
5 u; x- L3 O. o$ e(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,
  I, E5 a3 ]5 j' U1 }Shanghai Jiaotong University, Shanghai 200032, China)
" b4 [; C) \/ kAbstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is9 q. j- T* a; d: O, l
still unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of- U3 i1 E7 F: g- u1 d& ^6 `- j
knowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily
6 H) C) y( Q6 d6 i7 icharacterized, which might provide a novel clue for explanation of tumorigenesis and establishment of
. i% m! s9 _5 t5 ], Y2 Onovel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the6 m" d8 r; C  h; f
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
# O% m+ ~: k% O* z4 U  hrecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug
7 u+ R* m# O  w# [+ ~resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as; n0 d5 H- }) |/ d" V
many problems that remained to be solved.
. P" B7 n! Z1 l0 X" L* c; B8 aKey words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

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passenger101

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见闻

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lanbaiping

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yfancying

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