癌干细胞研究进展

sciential

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4 n5 c+ F+ Z( k8 i/ `李锦军，顾健人*) x- P) r9 L: b( [2 i! B& k/ c
（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
9 S& s- h7 h$ a$ S摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知
/ T  {7 ~' L. G: B$ i识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病
$ b: E. `3 `: `5 X. v机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我- j. r0 M( \) t% r% R! f- v7 R
更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与6 o, P; z4 r) [! A& P
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作
& k1 j" S5 n3 e: k! }4 `1 w一综述。2 o" ]* m( ]+ M8 R+ l1 ^" B
关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生6 B0 n) R! A% j0 w/ D' W
中图分类号：R730.21; R730.231　　文献标识码：A
, T' S2 w4 G# Y7 hRecent progress in research on cancer stem cells
. d9 u) r9 k2 g# Y! P* O& @# CLI Jin-Jun, GU Jian-Ren*
0 X, O0 C0 S+ A+ K: [(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,) Y  }3 H0 w" h# s
Shanghai Jiaotong University, Shanghai 200032, China)
' c7 V6 B# h' }# [# a+ L- ?, S+ o5 xAbstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is
$ v% m, @8 v$ ystill unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of1 Z" c  P6 M) W5 u6 w) {* L7 ^
knowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily
; I! i4 m7 X% H" d9 o/ H8 d- Fcharacterized, which might provide a novel clue for explanation of tumorigenesis and establishment of
' M2 q1 ?8 h# ^7 z+ ]6 K: \novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the4 }# n, `4 H* b
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
! O8 O; {$ `6 r: g4 Mrecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug
/ B5 h5 l: l8 [1 p' kresistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as0 u! N" Q$ d0 l: @. M
many problems that remained to be solved.. o1 p; [/ g' f5 ]) j
Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

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passenger101

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见闻

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lanbaiping

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yfancying

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