癌干细胞研究进展

sciential

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李锦军，顾健人*
( r: |: @! m5 V4 T( V（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）5 [  s* U) U8 M' ]1 v% U+ V
摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知% b" V" \/ W( y8 E0 b
识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病
2 _$ l! {& v. P1 i机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
% s/ t( K  H2 I# e9 K更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与- Z: n! ]% Y6 ?; K% E
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作: F) I! J; T: {5 g4 G$ q# H
一综述。
" ^9 f0 L0 V) _3 e% q关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生  ]$ }1 r8 n, K2 A
中图分类号：R730.21; R730.231　　文献标识码：A, L! M- D+ F1 m/ R/ ^
Recent progress in research on cancer stem cells
; U  m  |$ F4 f% wLI Jin-Jun, GU Jian-Ren*
7 A) Q1 B: a6 z! K, a/ G(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,
1 i) ^& P: H- t0 T" WShanghai Jiaotong University, Shanghai 200032, China)& F6 F  n+ |4 j0 o5 L
Abstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is
( Y& n# s/ t  b1 g1 |1 Z: r# J8 Qstill unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of
# l" R  ~2 q- O1 S: Uknowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily1 I; W# \# Y6 R# k
characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of
# N* u) A9 ^2 j6 G2 w/ a! pnovel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the! h5 o# |. L9 g% Q8 E: W; Y9 l
properties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
. g8 c* v# Y2 p! orecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug
: `% {7 w6 L; l, e# ~* Nresistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as+ ^0 ~* C3 n# F+ b9 o  e$ p, J
many problems that remained to be solved.
6 S( [4 m) B2 CKey words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
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% V# i: i, C3 V& o0 r/ v+ K7 s% g$ E附件为全文，请大家支持一下 回复本贴就可以下载了" d: M, U! d& ?

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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

thanks

passenger101

couldn't open it.

见闻

thank you!

lanbaiping

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yfancying

好东西