癌干细胞研究进展

sciential

; |1 i+ ~; P/ ^# F; E
4 x! \+ z  C# }
李锦军，顾健人*4 R+ ~% X9 m0 }2 a6 J
（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
3 o! ~! l- J8 q5 _" b摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知
6 i  [; e% ^) [  j5 d9 x( W识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病1 o) z* m8 s* P3 u/ q  M* D) b( f
机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
) `# ]2 Y9 {# L: r) C7 R更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与! U: U- a4 W, R2 c+ c
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作
4 v$ x) G+ ^- w# m* s/ a一综述。4 T2 h; c9 A2 w1 E
关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生
$ w8 {: B( W5 ?. h中图分类号：R730.21; R730.231　　文献标识码：A
# Q0 V# ?: h/ R2 U3 ?Recent progress in research on cancer stem cells$ g8 C1 r$ P. f1 L
LI Jin-Jun, GU Jian-Ren*" F% b& {  K0 J' X# g- c
(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,  C. N; q- O  H: v
Shanghai Jiaotong University, Shanghai 200032, China)
9 e0 L6 L5 L2 v2 T1 TAbstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is
  G( z3 K4 C7 j; @; W% T! w' hstill unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of
/ g2 g7 G3 [3 a! g* uknowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily$ q, u. ?, e6 q2 I
characterized, which might provide a novel clue for explanation of tumorigenesis and establishment of# \, r* e7 F6 T9 u! U
novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the
' b1 Z8 R4 O0 wproperties of self-renewal, strong potentials of proliferation, which might play important roles in progression,
. k9 Y* U: V5 crecurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug9 a: H" N* W  X
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as' X) L; p3 g6 p9 I5 A: b
many problems that remained to be solved.
0 Y& H7 L& S% c& l0 O3 Z( o# ^, ?Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
$ o. ]& y' _- c4 X4 w% a7 I
! y# ]+ f8 K) ^$ y8 g6 k/ `附件为全文，请大家支持一下 回复本贴就可以下载了7 R3 `+ W) W- d, p# e- ]

2 s" ^2 _) {+ O

horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

123

1# sciential

passenger101

thanks

passenger101

couldn't open it.

见闻

thank you!

lanbaiping

很好的东西，收藏

yfancying

好东西