癌干细胞研究进展

sciential

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李锦军，顾健人*
9 n& R" f0 ~' k& A6 K6 d（上海交通大学上海市肿瘤研究所癌基因及相关基因国家重点实验室，上海200032）
0 V, V. |- v7 P摘　要：关于肿瘤发生及发展的机制人们已探索多年，但由于肿瘤病因本身的复杂性、研究技术和知
- |' J' n: e% a识积累不足等各种原因，研究进展缓慢。近些年来，癌干细胞的发现、确认和特性研究为肿瘤发病
, Z3 V' y6 W" ^$ a8 |机制的揭示，乃至新型高效治疗策略的制定提出了新线索。许多研究成果显示，癌干细胞因具有自我
/ N' ]2 {& I8 R: A+ U3 n8 X9 H) g更新和潜在的强增殖能力，在肿瘤发生发展、复发转移中均发挥着很重要的作用；肿瘤化疗的失败与7 {8 {8 w% h& L0 r, D8 ~/ }, Y7 ~: B
肿瘤组织中癌干细胞的耐药性可能存在密切关系。本文就癌干细胞在这方面的研究进展及存在的问题作
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关键词：干细胞；癌干细胞；自我更新；耐药性；肿瘤发生
6 }# E9 Z/ l7 X9 W/ B+ c中图分类号：R730.21; R730.231　　文献标识码：A0 I$ O- Q6 p# x0 }) z1 @
Recent progress in research on cancer stem cells3 L* e( i  U& `7 V- ]/ }: o
LI Jin-Jun, GU Jian-Ren*0 S' R4 s; B6 f/ q7 w; G
(State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute,& S4 [7 `0 s- b7 ?. Y1 l6 U
Shanghai Jiaotong University, Shanghai 200032, China)4 I4 T# i6 C- p* _6 l4 n8 k- J4 {4 P2 m
Abstract: Mechanism of carcinogenecity and cancer progression has been explored for decades, however it is4 g$ _8 y1 N* Q: p3 V# [
still unclear because of the complexity of carcinogenesis progress, the limited techniques, and lack of
9 g, f; _' l' h1 Rknowledgements. Recently, cancer stem cells from several types of tumors were isolated, identified and preliminarily
9 L# Z) ]; T8 i% Gcharacterized, which might provide a novel clue for explanation of tumorigenesis and establishment of  E$ ]+ k0 |" T/ }7 R6 z% _
novel strategy of effective chemotherapy. Many reports have suggested that cancer stem cells possessed the
# M9 q/ L' x, A/ jproperties of self-renewal, strong potentials of proliferation, which might play important roles in progression,& O! Q: M8 x& K, ~  O: v4 t
recurrence and metastasis of cancer. Meanwhile, chemotherapeutic failure may be associated with the drug/ u% x$ U+ q5 V: C! P0 ]
resistance of cancer stem cells. This review described the recent progress in cancer stem cell research as well as
2 m$ h  p& C+ \: U# n% i, a4 S6 hmany problems that remained to be solved.+ U7 T, c$ |# O, u9 U8 Z* `; h
Key words: stem cell; cancer stem cell; self-renewal; drug resistance; tumorigenesis
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horst

真是好资料，很有帮助，谢谢了

icanfly2011

谢谢了

icanfly2011

谢谢了

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1# sciential

passenger101

thanks

passenger101

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见闻

thank you!

lanbaiping

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yfancying

好东西