干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研: Z4 v/ e- C8 Z, _; `1 q, I
究生院 北京市 1007305 Z9 w. S' N( j; Y' y
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学, Q7 O; I5 Z6 ?
科学院中国协和医科大学中日临床研究所. qianbo79@163.com
2 y2 \5 o/ _6 v2 e9 ]电话: 010-84206005 传真: 010-64206643
" [: Y2 N4 E& a' X2 @' c收稿日期: 2007-03-17 接受日期: 2007-04-25" a- j$ P' H" k8 @) p' v
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Association of stem cells+ |& d9 g. h2 C( n$ {8 Z; A8 \- G8 X
and cancer stem cells with- I6 t: \9 h% B
tumorigenesis
7 k( X3 z) [1 ?2 B, {Bo Qian, Han-Qing Cai, Jie Feng
' V) ^; Y( D" _0 V# MBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of, I6 u8 ~' {" e  q4 m
Peking Union Medical College, Chinese Academy of Medical) ^. C0 o9 Q- E7 B2 |; X% h9 p
Sciences, Beijing 100730, China' G$ l4 U0 Z# |2 n  @/ y8 {
Correspondence to: Bo Qian, China-Japan Clinical Research0 L5 S2 H1 X' ?# j, b* V  I! n
Institute, Peking Union Medical College, Chinese
" }7 ~, y  b: g. A! Q; NAcademy of Medical Sciences, 2 Yinghua East Street, Beijing
4 K8 P8 T6 K/ w6 t100029, China. qianbo79@163.com5 ?- g. m4 i) _# {
Received: 2007-03-17 Accepted: 2007-04-25' R* S$ P* ^6 l! V" p' n
Abstract
( S* `# w  @( k0 oThe research on cancer stem cells is a new hot
  N! X; v6 N/ \8 D$ R% _spot in at present. The hypothesis indicates
/ K7 Y$ Q  G, ^) X8 ]# P3 mcancer stem cells, which were possibly the origin
' S3 m2 E' X* i1 P. H/ m" k9 S/ Uof the cancer, come from normal stem cells. For
* K2 s" A6 u* n& g3 g3 Wtheir special characters, normal stem cells can
6 ], V# ]9 S% wdifferentiate into tumor cells more easily than: E3 G2 Z' A9 A+ ^
adult cells. Stem cells transform into malignant4 k2 _, a8 U0 b; y9 a' w
cancer stem cells possibly because of gene+ A. s: k  k  G
mutation, abnormal asymmetry and cell fusion.
& g. H2 S. I5 gIt is a main method to obtain cancer stem cells by
9 d$ W/ U7 X) B( _% g+ a* [% Iflow cytometer using different protein markers$ F8 f# i& m; P& Q
and fluorescent probes. It is demonstrated that# F2 |  f$ F# T/ Y
cancer stem cells are very powerful in selfrenewal,
2 Z) }$ s7 d) b  }3 d2 \proliferation, and differentiation.9 Y1 A! \, z1 v0 H7 H6 c8 C
Targeting on cancer stem cells, early diagnosis( j- K5 s' t+ g/ s: w( z2 j
for cancers might be achieved.
- R2 R2 o/ f$ m- {9 ]1 |" b5 C- ~. sKey Words: Stem cell; Cancer stem cell; Cell differentiation;* ]  p5 S: p9 Q# T! B& N7 a& r% V
Tumorigenesis; Flow cytometer# ?! u2 D+ v* ]9 p- X7 g
Qian B, Cai HQ, Feng J. Association of stem cells and" t- Y9 g& z! l9 E
cancer stem cells with tumorigenesis. Shijie Huaren$ J5 _1 E3 V- v! M% U% x4 x
Xiaohua Zazhi 2007;15(13):1526-15318 S2 B' Q* y& m5 e

7 o9 ]% ^" q3 |0 H% {* p摘要; s7 c5 M0 g8 p8 g! ]
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
; {( W' u% b/ C' i0 M由正常干细胞恶变形成. 正常干细胞的特有性
9 @8 G; {& H/ m6 z7 v& H. x" \状, 使其较成体细胞更易成为肿瘤发生的靶细
# a/ U2 f$ F+ H( m胞. 干细胞可能经基因突变、异常不对称分裂( j$ a, r8 R5 K0 ]+ L! Y2 T4 q
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
: O$ a0 Y0 ]2 s7 |+ x白标志物或荧光探针, 通过流式细胞仪分选是# i* w+ w4 S0 L. l; R
发现肿瘤干细胞的主要方法. 已证实的肿瘤干- ?3 f, ]; @: V7 ]3 H, p  ?
细胞皆具有强大的自我更新和增殖能力, 以及2 S, @# y  v* ~1 s/ F. y4 f
细胞分化潜能. 针对肿瘤干细胞的检测和杀
" q# a$ {7 t+ r& \0 u5 s伤, 可能为肿瘤早期诊断和治疗带来希望.. q+ B) C( z# w
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;. C% I4 b" w: c$ V+ S. o0 ]4 G0 l
流式细胞仪- H0 y& O+ u) E8 k8 I

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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chenghoby

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