干细胞、肿瘤干细胞与肿瘤发生

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+ K( T& ]: a0 q7 i5 z- }' |- `钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研4 `, \4 C. Z$ e  N  k2 t4 H
究生院 北京市 1007307 E0 x& P( R% {" h- Q3 `; J+ U: J
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学; u: v& x7 L! i- e+ ]) Y
科学院中国协和医科大学中日临床研究所. qianbo79@163.com, r( V" }) W/ w1 A2 {
电话: 010-84206005 传真: 010-64206643" C$ ?# d, X, O9 B/ u$ L
收稿日期: 2007-03-17 接受日期: 2007-04-25
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Association of stem cells
# Y# ^9 B8 o2 W6 n! t/ x4 P( P0 hand cancer stem cells with
  m9 V2 f* D* Ntumorigenesis
  ]: `% J. p& @2 ]1 FBo Qian, Han-Qing Cai, Jie Feng
  i% w0 S- @+ A6 iBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of7 r  g, W5 ^6 l! P! J3 B
Peking Union Medical College, Chinese Academy of Medical
( C% E4 J4 ]( n+ Y8 Z  t! qSciences, Beijing 100730, China
% D% |" ~+ x& d( QCorrespondence to: Bo Qian, China-Japan Clinical Research
, M- p& D) N2 PInstitute, Peking Union Medical College, Chinese
8 l) B6 i  j: N# `  v+ nAcademy of Medical Sciences, 2 Yinghua East Street, Beijing
! l: O0 a1 w+ \! T100029, China. qianbo79@163.com4 M+ g+ q  d7 ^+ D
Received: 2007-03-17 Accepted: 2007-04-257 |5 L( S. T$ N4 l0 Y; `
Abstract$ G+ w3 B" {% o9 w" D9 g
The research on cancer stem cells is a new hot( o, W8 h1 _' l$ I* K
spot in at present. The hypothesis indicates
- ~& o) }9 y9 P7 ocancer stem cells, which were possibly the origin
/ S0 W, W' [+ \' Jof the cancer, come from normal stem cells. For
+ J# T0 O' u" b; ~5 ~( ?6 j5 Ntheir special characters, normal stem cells can" V1 Q0 p5 }8 w! B# v
differentiate into tumor cells more easily than
( R- T6 r, e+ Y" X3 h# ]( ~% N  ^adult cells. Stem cells transform into malignant3 z0 v$ P3 @7 z+ S3 A( k
cancer stem cells possibly because of gene
9 W1 x) i0 n, V, I0 D9 [mutation, abnormal asymmetry and cell fusion.
2 g3 W/ a2 ?+ q7 ^& A2 P' PIt is a main method to obtain cancer stem cells by4 P; f3 B# q7 t" S2 L
flow cytometer using different protein markers# g2 ]! n$ B0 ]0 o- z& S
and fluorescent probes. It is demonstrated that0 O3 t6 c/ J4 p+ e8 S
cancer stem cells are very powerful in selfrenewal,9 y( J9 g$ j2 k
proliferation, and differentiation.
8 d4 P5 U! U# p& t/ X$ t+ P1 ETargeting on cancer stem cells, early diagnosis
- w& n7 L. J, r( c3 |0 s9 _) i7 nfor cancers might be achieved./ v2 ?: V5 m) X8 f3 S" U8 Z
Key Words: Stem cell; Cancer stem cell; Cell differentiation;, ]7 [( m, j+ _1 W
Tumorigenesis; Flow cytometer4 a4 ^! R7 w4 B5 \
Qian B, Cai HQ, Feng J. Association of stem cells and
' L4 d- ~7 V- ]- d+ Z7 tcancer stem cells with tumorigenesis. Shijie Huaren
; T0 u* N+ V" z. Q* Y7 t! ]9 nXiaohua Zazhi 2007;15(13):1526-1531: w# p6 v6 k# Z% S9 e
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摘要& k" x' g/ ~" q1 Z! n% L
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则/ e/ ~) b& r! H2 ~% N
由正常干细胞恶变形成. 正常干细胞的特有性
- {8 m, O0 C8 k- z& |状, 使其较成体细胞更易成为肿瘤发生的靶细
% _7 S7 ]; C) F' T  k8 o胞. 干细胞可能经基因突变、异常不对称分裂
: R1 t0 o4 S5 v8 S9 Y. y和细胞融合转化为肿瘤干细胞. 利用不同的蛋
# P( c, @% y  {; m/ y白标志物或荧光探针, 通过流式细胞仪分选是
. _0 [. k9 X7 ^' `发现肿瘤干细胞的主要方法. 已证实的肿瘤干6 j* b5 |0 o' y& ^) D/ r2 n
细胞皆具有强大的自我更新和增殖能力, 以及# A( g  P' f# ]; Z; D
细胞分化潜能. 针对肿瘤干细胞的检测和杀7 y1 P' c  Q; ^7 L4 b
伤, 可能为肿瘤早期诊断和治疗带来希望.
9 x" Y4 K" B/ G) B关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;, _/ H) _+ T. j2 U
流式细胞仪
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, }" ?! ?) b% x( V附件为pdf全文，请大家支持一下 回复本贴就可以下载了
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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