干细胞、肿瘤干细胞与肿瘤发生

gone

, g4 n6 w' v" m' C0 m
, V- J/ H% N/ Q8 n( N钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研8 M6 O* o' Q+ n6 n
究生院 北京市 1007308 L" L7 E" P9 o: a
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学5 n7 ]" P. ~. c1 ^" \
科学院中国协和医科大学中日临床研究所. qianbo79@163.com! o6 w+ ?- F6 Y8 i7 e* @
电话: 010-84206005 传真: 010-64206643
+ t3 L  w! J8 Z+ G/ ]" m' \7 h+ }收稿日期: 2007-03-17 接受日期: 2007-04-25
: c3 r% m% A2 ^' R9 `$ y
& P# o& G7 G% ~) o1 q$ F& ^# \Association of stem cells' b1 h6 B' w' r# c( w" Y
and cancer stem cells with1 x: r6 \& m" H1 W& c
tumorigenesis. _7 U. j; ?3 y8 w2 B
Bo Qian, Han-Qing Cai, Jie Feng
( U5 C9 ]4 n; }, ^8 _4 TBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of4 B# l3 W8 p/ k) p
Peking Union Medical College, Chinese Academy of Medical
% y' J* ~6 X( \  D2 {& x% T3 MSciences, Beijing 100730, China: U, q* p- X4 H& K' @9 @, d
Correspondence to: Bo Qian, China-Japan Clinical Research
) d$ y1 r6 y! J4 F$ I1 U7 f- GInstitute, Peking Union Medical College, Chinese# ^+ }$ @6 Y% \) `2 h
Academy of Medical Sciences, 2 Yinghua East Street, Beijing1 B' j8 u  s9 w! V0 z
100029, China. qianbo79@163.com
; v' L' H- h; l- S( b( CReceived: 2007-03-17 Accepted: 2007-04-258 Q4 s3 }6 j0 J4 y% ~0 B( v/ ]
Abstract
2 }( P1 G" j0 c, P' m% [The research on cancer stem cells is a new hot
3 P- W% W/ k; I' Sspot in at present. The hypothesis indicates
8 j2 u5 O- X2 S' }cancer stem cells, which were possibly the origin
# F3 R. q* ^/ iof the cancer, come from normal stem cells. For
. O% Z  `/ S4 m; N2 W7 Atheir special characters, normal stem cells can! ]5 p2 v( c' c1 b* @2 ]
differentiate into tumor cells more easily than, G% H" [/ f, G0 ^7 p# P  p
adult cells. Stem cells transform into malignant
6 s: |; q8 D3 P9 K& H0 m. r# ncancer stem cells possibly because of gene5 b! o2 ^! t* c0 R' ~. H8 b
mutation, abnormal asymmetry and cell fusion.# B5 Z/ K* f7 y/ N0 O
It is a main method to obtain cancer stem cells by
$ L5 g4 ~$ Y" z) s: Xflow cytometer using different protein markers
2 d  w8 U  y6 M! mand fluorescent probes. It is demonstrated that
' t8 y( i$ V: f7 xcancer stem cells are very powerful in selfrenewal,  J. ^* Z; @" C) B
proliferation, and differentiation.
% o+ b1 F+ U, G8 Q  P0 D; p: PTargeting on cancer stem cells, early diagnosis7 b  A5 m4 |+ K' }
for cancers might be achieved.: Y! T: t' q1 j: ~/ g7 r5 k
Key Words: Stem cell; Cancer stem cell; Cell differentiation;. n0 K: B" c! P1 F/ _# E
Tumorigenesis; Flow cytometer6 D( {" ]9 S3 r/ O' n) M
Qian B, Cai HQ, Feng J. Association of stem cells and$ q2 u5 w, O( {9 ?+ K: c
cancer stem cells with tumorigenesis. Shijie Huaren
9 D7 A3 Z+ k; [1 F$ C$ P- u7 lXiaohua Zazhi 2007;15(13):1526-1531
  A! S5 b( {, H3 S9 [
! ~$ y' |3 J4 E: J摘要
& g+ p* ?- g$ ?* u2 ]7 k* ^9 I$ ^& U肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则" v) j: N5 R4 ~
由正常干细胞恶变形成. 正常干细胞的特有性6 [- r5 k$ K% w3 X
状, 使其较成体细胞更易成为肿瘤发生的靶细. K3 W8 W) A* N3 M
胞. 干细胞可能经基因突变、异常不对称分裂8 j; H4 S1 Z# v
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
* l( x; Q4 L/ {6 p5 U7 ]  t白标志物或荧光探针, 通过流式细胞仪分选是6 i9 S* T4 A+ }  ^5 [3 ~4 ^
发现肿瘤干细胞的主要方法. 已证实的肿瘤干& _+ S9 W! Y) m) K
细胞皆具有强大的自我更新和增殖能力, 以及2 t" F/ _, I4 T5 u
细胞分化潜能. 针对肿瘤干细胞的检测和杀
! _- f' \& K. ?( y# [# T7 E伤, 可能为肿瘤早期诊断和治疗带来希望.
: P$ V2 N. \' M0 P* m' }7 k6 R关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
: ?0 N, L6 e( i' U. A! D流式细胞仪
5 r' Y0 p9 ^6 i$ I8 J! H& K; E- k% ?, l  n) c5 E# E. Y) }
附件为pdf全文，请大家支持一下 回复本贴就可以下载了! X  Z' S# T2 S% h5 m" A

+ o. C5 h  r! ?* H; P6 }

jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

good m

yfancying

1# gone
" q. g8 w3 ~' m辛苦了

1234567

不错不错~

chenghoby

谢谢

hualin840518

xuyuhappyfish

感谢，感谢~~~

zhangqh

正在读这方面的文献