干细胞、肿瘤干细胞与肿瘤发生

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) b# m& X+ |$ O6 d$ B钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研4 j7 C) l4 X$ t' N6 m( ?! N6 ~
究生院 北京市 1007308 E6 M9 ?. v" u" f. _
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学: H4 H: `5 e$ m. _2 {
科学院中国协和医科大学中日临床研究所. qianbo79@163.com; f$ ^) B4 Q3 g' d2 I- c$ ]0 q% G, A
电话: 010-84206005 传真: 010-64206643
0 `+ T$ Q" V0 j" R! H收稿日期: 2007-03-17 接受日期: 2007-04-25
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Association of stem cells3 `  k% ?6 W+ c) m4 u* G* A
and cancer stem cells with
+ a$ v; U0 U* \6 V4 ytumorigenesis
+ ?* w; \3 n4 }; g# t3 b4 f) f- ZBo Qian, Han-Qing Cai, Jie Feng' X2 f) T3 j' o) R% a
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of3 @8 a% m3 {, _& F& r
Peking Union Medical College, Chinese Academy of Medical) |+ E/ b: g4 {' I$ e$ ~8 y3 E5 ^
Sciences, Beijing 100730, China
9 [, S# R+ J1 eCorrespondence to: Bo Qian, China-Japan Clinical Research- z; N5 r. V5 X6 G
Institute, Peking Union Medical College, Chinese
+ R. y7 e2 {# D: jAcademy of Medical Sciences, 2 Yinghua East Street, Beijing
) |* i. V9 h4 f, c9 ]" y5 A100029, China. qianbo79@163.com
% @( @6 @0 {. V: JReceived: 2007-03-17 Accepted: 2007-04-25" E+ n: S, }7 Z& L. j, ^# O
Abstract
3 F2 f) J+ s# B, a9 `9 {9 @- jThe research on cancer stem cells is a new hot
# }% R* m& V' A. y4 D$ Z: y$ Kspot in at present. The hypothesis indicates
( U  b8 Z: ]# |6 C+ x4 L( tcancer stem cells, which were possibly the origin
( A6 Y3 J0 h/ @8 b# X- ?/ t* Q! C  iof the cancer, come from normal stem cells. For# A1 k/ \+ V% g& y1 |1 I
their special characters, normal stem cells can
( o5 U* j, n  z- r, Q7 o) {& Xdifferentiate into tumor cells more easily than
) e+ y  e/ [  a# x: n5 ^adult cells. Stem cells transform into malignant
' b* A9 S1 W- Qcancer stem cells possibly because of gene& V, @3 K9 {$ x4 z& N% D+ l
mutation, abnormal asymmetry and cell fusion.
) j1 Q) D( s  I$ k8 E% A  UIt is a main method to obtain cancer stem cells by
4 \% U2 }6 g9 @' \7 ?flow cytometer using different protein markers
% D) \4 o$ P' i- a4 {and fluorescent probes. It is demonstrated that0 \6 L) ?/ @6 F0 N, S5 u: O7 e  y
cancer stem cells are very powerful in selfrenewal,
0 v5 W+ ~+ J4 z% Aproliferation, and differentiation.% X' F/ g6 x; z7 W
Targeting on cancer stem cells, early diagnosis
3 a/ Y& ]3 G" A% {6 P; {for cancers might be achieved.  v7 M* ?2 }8 p  c. l. |& a0 X
Key Words: Stem cell; Cancer stem cell; Cell differentiation;
1 N( ~/ |- ~/ n# v" B, d, ^Tumorigenesis; Flow cytometer
4 P6 R; W3 S7 o1 k" i' B- KQian B, Cai HQ, Feng J. Association of stem cells and/ ?& M' |4 J5 K! b& k! u( c, X
cancer stem cells with tumorigenesis. Shijie Huaren0 Q1 g. h6 v5 ^! U
Xiaohua Zazhi 2007;15(13):1526-1531* q# m+ U) a* g) O8 {' E
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摘要
6 q- ^7 x1 O2 v% c肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
0 b( Y1 C/ |# A" S8 V由正常干细胞恶变形成. 正常干细胞的特有性3 U; R) ]1 e. v
状, 使其较成体细胞更易成为肿瘤发生的靶细
$ d+ R$ Q' U8 M9 ]$ m胞. 干细胞可能经基因突变、异常不对称分裂8 M* a" i1 N6 m% a$ w
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
9 H7 b; A7 b6 U白标志物或荧光探针, 通过流式细胞仪分选是3 K/ q$ w& l" Z! Z/ m6 U) n5 s2 Q0 n
发现肿瘤干细胞的主要方法. 已证实的肿瘤干; k/ F$ g# \+ `# W& l4 V6 Z1 w
细胞皆具有强大的自我更新和增殖能力, 以及
0 q. W3 A9 x8 \6 S细胞分化潜能. 针对肿瘤干细胞的检测和杀2 q: d3 I- E, Y* a4 q
伤, 可能为肿瘤早期诊断和治疗带来希望.* s% \4 L5 t6 z9 k- O2 N  l) n5 o5 J+ |1 N
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
+ i- j8 l9 ~& U! d流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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yfancying

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xuyuhappyfish

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