干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研# j# A( ~! @. l  j: S
究生院 北京市 100730
& F5 b' g1 H- ]5 M通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学# B0 G4 [  p* V. _
科学院中国协和医科大学中日临床研究所. qianbo79@163.com
6 b' Q+ u+ ^; q7 C电话: 010-84206005 传真: 010-642066436 ]2 C, n2 u$ i: Y" K+ K8 P
收稿日期: 2007-03-17 接受日期: 2007-04-25
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3 |2 e9 n/ c2 S/ T' j; zAssociation of stem cells: _+ g8 y! _. c& z
and cancer stem cells with
# ?. G' e( V# b. Htumorigenesis
. ^9 G5 D+ |9 n9 ]) w9 r9 M- }Bo Qian, Han-Qing Cai, Jie Feng
1 {' j, M4 `; B8 ^. j- P. G% P& cBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of: D+ w! s9 l, H/ r! z3 c
Peking Union Medical College, Chinese Academy of Medical
1 S0 Q& ]3 b  |. M( |: VSciences, Beijing 100730, China
1 d, l: Q/ @# KCorrespondence to: Bo Qian, China-Japan Clinical Research
- u3 _1 S/ y) h& D) ?( d; \Institute, Peking Union Medical College, Chinese, M. V+ O3 n/ m* O, x6 K" m
Academy of Medical Sciences, 2 Yinghua East Street, Beijing
6 X# S  ^, W. g0 d+ r" Z! l3 v, I100029, China. qianbo79@163.com5 N. e, p! Q- `* C1 v, _" C6 U
Received: 2007-03-17 Accepted: 2007-04-25
% o4 g/ \/ W  {  |Abstract
7 Z4 R6 E4 ?  b  ~/ y! ?% [' LThe research on cancer stem cells is a new hot1 @6 A& s( ]  _3 K2 e- q& P
spot in at present. The hypothesis indicates
% q: Q) _( X, O& [9 Lcancer stem cells, which were possibly the origin
0 \8 F/ o/ m4 a/ ?7 q; Y4 Z& ]/ ^  pof the cancer, come from normal stem cells. For
! M1 n" [( D% y7 b* Ktheir special characters, normal stem cells can0 S4 W: W! q2 S8 I
differentiate into tumor cells more easily than9 A$ Y+ \  x0 y9 d4 j; [
adult cells. Stem cells transform into malignant% @6 S8 p: G; w( F) k/ E
cancer stem cells possibly because of gene# w" D1 I' g. K& |4 b- o( x
mutation, abnormal asymmetry and cell fusion.
) A( W" t4 m9 d& Z' UIt is a main method to obtain cancer stem cells by
0 u) F4 i1 U1 D" Fflow cytometer using different protein markers
3 V" ^. w  S7 Jand fluorescent probes. It is demonstrated that
% Y0 A  T2 X+ N2 W: ocancer stem cells are very powerful in selfrenewal,: ?3 X" C& O3 q$ e* D& `
proliferation, and differentiation.  C0 O' W% [$ G) j
Targeting on cancer stem cells, early diagnosis! h' K- k, u# s, e8 P2 K
for cancers might be achieved.! K/ A( m1 W1 y3 z# j) Y1 z% e! ^
Key Words: Stem cell; Cancer stem cell; Cell differentiation;+ `/ p) J6 O" u+ p% ^
Tumorigenesis; Flow cytometer$ ]4 }+ K/ ~$ q7 E3 X
Qian B, Cai HQ, Feng J. Association of stem cells and
, r6 ]5 Q- ]$ h- ~! Ncancer stem cells with tumorigenesis. Shijie Huaren
% M) @, p2 h/ ]9 N7 i- }Xiaohua Zazhi 2007;15(13):1526-1531
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2 b2 e% ~3 O- n* C摘要
% _8 v4 F6 z" O  D, [7 _3 i肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
! ~. g* q/ p7 k由正常干细胞恶变形成. 正常干细胞的特有性
: n. R5 Z' T8 W状, 使其较成体细胞更易成为肿瘤发生的靶细
/ I1 {% Q! g7 B. S8 G# t6 x0 ?9 h胞. 干细胞可能经基因突变、异常不对称分裂
; K) h9 n# T* h$ J7 b3 t" ~: L和细胞融合转化为肿瘤干细胞. 利用不同的蛋8 b2 V: X7 D5 i4 @* [1 b
白标志物或荧光探针, 通过流式细胞仪分选是
/ r* @5 Q* S4 t& |. Q  b发现肿瘤干细胞的主要方法. 已证实的肿瘤干4 ]9 W- i, k# G7 X( g" z
细胞皆具有强大的自我更新和增殖能力, 以及
2 r. ~  A1 v; L/ |/ F细胞分化潜能. 针对肿瘤干细胞的检测和杀* K  Y5 t& e, q  O' A& A$ f8 \  Y
伤, 可能为肿瘤早期诊断和治疗带来希望.
" z: C0 i1 ^& q5 N/ h6 [关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
, m( I: l9 [% S% N. K流式细胞仪
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jitianxing7021

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