干细胞、肿瘤干细胞与肿瘤发生

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5 g) f6 r; R& H3 M' Y2 @0 z3 d0 `钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研7 n; c6 c0 f1 l& Q7 M
究生院 北京市 100730
3 U+ I7 {5 |3 j' J$ G- Q/ G通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学1 K2 C+ Q# P1 b$ _2 V$ [9 M) t3 s
科学院中国协和医科大学中日临床研究所. qianbo79@163.com, t4 M/ b0 f, J( X' \0 ^1 z
电话: 010-84206005 传真: 010-64206643
9 z/ @+ t4 D* T" q4 _$ d+ Z收稿日期: 2007-03-17 接受日期: 2007-04-25
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Association of stem cells; f& V) G, \3 u: Z9 B5 X- ]
and cancer stem cells with
  b: K: D% ]( B. b; Ttumorigenesis
# V, v" H+ X8 r' nBo Qian, Han-Qing Cai, Jie Feng/ ^; T  E0 u3 d8 K$ |$ c6 S: X8 j
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
! r5 q* g5 Y- m3 x' V6 y( J( m1 gPeking Union Medical College, Chinese Academy of Medical0 g, }. f: G: m% @8 a
Sciences, Beijing 100730, China- m& ?; L. @3 ]% `$ d
Correspondence to: Bo Qian, China-Japan Clinical Research/ e" H8 u0 {* B; |% L9 K4 X9 h
Institute, Peking Union Medical College, Chinese6 K+ Q  U. u* t# w4 X; [& \
Academy of Medical Sciences, 2 Yinghua East Street, Beijing: _: D' u% a) e$ y7 T
100029, China. qianbo79@163.com
+ ^; z( E( s! X- [& z. sReceived: 2007-03-17 Accepted: 2007-04-25* [: K: P$ F: O5 s% R
Abstract7 Z/ J8 C; j. q) F
The research on cancer stem cells is a new hot9 [7 N+ X( ?4 F" j( c# P2 a& ]+ t5 F
spot in at present. The hypothesis indicates5 K6 `4 f' _9 i/ |% y, l% B7 @
cancer stem cells, which were possibly the origin
) ]! Z0 r2 H' C/ Q- V$ Kof the cancer, come from normal stem cells. For
' p3 e# I  ]8 A0 |8 Ptheir special characters, normal stem cells can9 R/ d( f6 m( G& a
differentiate into tumor cells more easily than
7 K$ y8 b: I. \0 }7 xadult cells. Stem cells transform into malignant; e  V, u' r8 W' `! b* y
cancer stem cells possibly because of gene/ N' W, k9 W5 p$ \: P" C9 Y& B6 X
mutation, abnormal asymmetry and cell fusion.2 h$ F" h9 Y; \% s$ s6 F: P6 x
It is a main method to obtain cancer stem cells by: M2 Q/ G/ x+ }, {$ m
flow cytometer using different protein markers
1 \: A; n) x# p" I  W( T0 }/ jand fluorescent probes. It is demonstrated that+ a7 }9 O4 |3 X7 _$ @6 M6 k: G: t
cancer stem cells are very powerful in selfrenewal,
& D) Y: k+ V5 k: I& `0 u  Kproliferation, and differentiation.7 u4 x- j% V3 U4 t
Targeting on cancer stem cells, early diagnosis; s  U8 o) k. C% R8 }( \
for cancers might be achieved.# ?1 H8 d* l/ N
Key Words: Stem cell; Cancer stem cell; Cell differentiation;. s. |( Z$ T. R; i/ N
Tumorigenesis; Flow cytometer1 b9 w7 A; [3 P
Qian B, Cai HQ, Feng J. Association of stem cells and8 }6 @0 `8 T, K8 Y# W* H7 j9 Z7 ^
cancer stem cells with tumorigenesis. Shijie Huaren2 n5 [' r6 e' s- R7 I
Xiaohua Zazhi 2007;15(13):1526-1531: o5 k9 }7 a) P1 [4 f6 Y0 Q

2 q( I9 c  o4 q% W( [6 @摘要
+ [0 }) t" D/ s% c4 y! D肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
, U& Y# f) I4 A4 f由正常干细胞恶变形成. 正常干细胞的特有性# G* P% T2 A' v3 r5 S$ ^
状, 使其较成体细胞更易成为肿瘤发生的靶细7 M% v" t4 T/ x
胞. 干细胞可能经基因突变、异常不对称分裂
% V- Y6 w7 ]9 q和细胞融合转化为肿瘤干细胞. 利用不同的蛋" Z# d; u5 o  }! [
白标志物或荧光探针, 通过流式细胞仪分选是
5 j4 w0 W2 t- G  o+ {  x: r发现肿瘤干细胞的主要方法. 已证实的肿瘤干
2 W& S2 T8 [9 @. |1 x, B1 }% g7 S细胞皆具有强大的自我更新和增殖能力, 以及3 j3 s% v( @: j0 O* a8 w2 c! S
细胞分化潜能. 针对肿瘤干细胞的检测和杀
3 H$ i5 _0 N% G" e, y伤, 可能为肿瘤早期诊断和治疗带来希望.
  j) }# `3 E" l, |" v9 v关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
9 s3 t, ]% u# {* S流式细胞仪
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2 G6 [) b2 o1 y; v- T2 H附件为pdf全文，请大家支持一下 回复本贴就可以下载了9 z, W: r9 [9 j$ Y4 [
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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