干细胞、肿瘤干细胞与肿瘤发生

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5 E! g" l. T- ]) d6 `( B" f钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研* B9 o9 g- ~9 c# h
究生院 北京市 100730, y4 _2 V, _% {; t
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
1 c9 Q: L7 H0 k1 n& d7 u& }科学院中国协和医科大学中日临床研究所. qianbo79@163.com2 A+ P' h/ h$ k" D& o3 x
电话: 010-84206005 传真: 010-64206643
8 t# W5 t7 R; [0 m7 y- a* U收稿日期: 2007-03-17 接受日期: 2007-04-25
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1 s# }0 \2 _  l  w! OAssociation of stem cells' G; c9 G3 J3 G
and cancer stem cells with
5 E, H/ @$ L. p) C& I& x0 X, vtumorigenesis
2 e- |' O7 B7 fBo Qian, Han-Qing Cai, Jie Feng
, y! E& r- v3 L2 o( X: E1 S5 oBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
, k5 |+ w. U; {( F) U9 ^Peking Union Medical College, Chinese Academy of Medical  y9 m/ U0 k- C* O) l
Sciences, Beijing 100730, China# N, T! n: D& \, k: M3 x/ n; ~5 L
Correspondence to: Bo Qian, China-Japan Clinical Research
- K1 O) n# U& T/ t! rInstitute, Peking Union Medical College, Chinese
: D( I. R+ Q0 T0 xAcademy of Medical Sciences, 2 Yinghua East Street, Beijing5 z: k. o/ A! G  F
100029, China. qianbo79@163.com7 Z) b, I. H2 i1 j! g& S
Received: 2007-03-17 Accepted: 2007-04-25
5 s+ H7 Q) r; p1 K# hAbstract
0 [- B# c+ A- pThe research on cancer stem cells is a new hot1 l: w+ I3 O+ U1 O0 @* h
spot in at present. The hypothesis indicates# w) G( f& z6 {$ ~
cancer stem cells, which were possibly the origin
6 J5 Z3 K* m  @' T* kof the cancer, come from normal stem cells. For
) x7 _0 i: f" O% ]  P; |their special characters, normal stem cells can7 y5 Y6 Q' }1 C7 C9 M/ a  C% Z
differentiate into tumor cells more easily than; [* A+ S' V! S/ S" T; F+ u& ^
adult cells. Stem cells transform into malignant
$ {3 F( I% `7 L& B$ o% Kcancer stem cells possibly because of gene5 x. A/ w5 ]) @
mutation, abnormal asymmetry and cell fusion.$ Q+ O9 `0 V9 }! m& `
It is a main method to obtain cancer stem cells by- I- M4 E: d0 j4 M+ z8 t" K3 K
flow cytometer using different protein markers& \: S9 [; d# i- i: o) S
and fluorescent probes. It is demonstrated that  `# f+ {# }; p, ?/ M& ]
cancer stem cells are very powerful in selfrenewal,
5 E" v" i% j# Q/ Hproliferation, and differentiation.5 w4 S! K  Z) D2 a5 |+ D
Targeting on cancer stem cells, early diagnosis
6 Q& f* X0 @+ c: s. Xfor cancers might be achieved.
0 W1 H5 h0 x' A, L! W# `& CKey Words: Stem cell; Cancer stem cell; Cell differentiation;. Z# k1 f7 Z  n5 `  e7 ^( O+ z6 B5 e
Tumorigenesis; Flow cytometer
. ]% }4 p* |: j5 {+ d9 z4 lQian B, Cai HQ, Feng J. Association of stem cells and0 j3 z, z- H0 R
cancer stem cells with tumorigenesis. Shijie Huaren. {( [" [& \! V, a. Q- ?5 E
Xiaohua Zazhi 2007;15(13):1526-1531( _/ J2 k3 I( v' `! Z7 |

0 c' J/ ?/ q- y" ?" z) U摘要1 `& O) k3 q. A. h
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则$ [- q! {$ B3 f$ \
由正常干细胞恶变形成. 正常干细胞的特有性0 V4 L  l) C+ w
状, 使其较成体细胞更易成为肿瘤发生的靶细
! G7 n; ]. Y2 i# a! D' K' k; A5 _' p& ]0 K胞. 干细胞可能经基因突变、异常不对称分裂5 B2 e: W) b6 n2 L  D$ m8 ~7 r
和细胞融合转化为肿瘤干细胞. 利用不同的蛋! _7 e& @4 f' Q* v/ i
白标志物或荧光探针, 通过流式细胞仪分选是
/ O! O0 H+ X# H6 ?  D发现肿瘤干细胞的主要方法. 已证实的肿瘤干
8 _& ^5 `2 U* G! u) b细胞皆具有强大的自我更新和增殖能力, 以及( ?- }4 B% i% j, p  @
细胞分化潜能. 针对肿瘤干细胞的检测和杀+ }9 k5 T& @( Y! }. ]
伤, 可能为肿瘤早期诊断和治疗带来希望.
9 v! F1 H5 k' `! W& h/ `关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
. K) G* o# R+ R' @' N流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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yfancying

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辛苦了

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