干细胞、肿瘤干细胞与肿瘤发生

gone

+ H" Y; u/ U& W% _5 C5 n% z; x& T, L4 k# r  _
钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研% i/ C: i& ^* G
究生院 北京市 100730$ D  D( \7 a8 W4 X6 p
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学6 h+ [1 m9 Z, x) U7 r* l
科学院中国协和医科大学中日临床研究所. qianbo79@163.com
$ r5 P3 E! ]/ A; p9 x电话: 010-84206005 传真: 010-64206643
5 i; o: J! G) K# q$ G' @+ m收稿日期: 2007-03-17 接受日期: 2007-04-25) n2 n5 W* G7 r% L# A& X

0 t7 r, ^* a; dAssociation of stem cells
+ F  g" a1 |( K& M( j' Kand cancer stem cells with9 E& X; [8 q' y" g& Y
tumorigenesis
0 D: |' N2 M4 N) ]2 T; ]' a) ]Bo Qian, Han-Qing Cai, Jie Feng0 C% `2 [  V8 e, |6 y" `
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of/ N/ i9 A% M- g, ~
Peking Union Medical College, Chinese Academy of Medical/ n, E1 `) U3 O9 n( t
Sciences, Beijing 100730, China) q* _$ y4 w7 R" e
Correspondence to: Bo Qian, China-Japan Clinical Research
/ f4 R* N7 y, f2 XInstitute, Peking Union Medical College, Chinese* l9 F+ g3 ~' c9 \. q* s+ ~
Academy of Medical Sciences, 2 Yinghua East Street, Beijing
9 S* x! z. u+ h5 x$ M) y100029, China. qianbo79@163.com# F; N" v0 F4 x" b
Received: 2007-03-17 Accepted: 2007-04-25: L8 D% s/ c5 b3 P2 p. e
Abstract
% K) f* j% D! a. D2 z& @3 ?+ k# PThe research on cancer stem cells is a new hot# S! z( a3 @/ ]/ g0 F' z6 s
spot in at present. The hypothesis indicates
1 u) R# V& Z% }# u3 qcancer stem cells, which were possibly the origin1 @$ Z6 Y. v1 \* s3 @5 u8 t% ^
of the cancer, come from normal stem cells. For4 e9 x8 `/ G# P
their special characters, normal stem cells can: {& C& z8 N8 G: t1 o0 a7 P% m
differentiate into tumor cells more easily than
& O3 W9 b# C, e, _2 }; A4 B0 K1 eadult cells. Stem cells transform into malignant
0 Z, i" Z# z5 c/ ycancer stem cells possibly because of gene
  a  b2 K3 i5 f, S5 L  dmutation, abnormal asymmetry and cell fusion.* S2 ]& H- z0 A5 k! d
It is a main method to obtain cancer stem cells by
6 c9 e! M- h; z% d0 _flow cytometer using different protein markers' t& h. |6 d( c" L/ {
and fluorescent probes. It is demonstrated that
5 w) E; [  G: p' J+ q; Ccancer stem cells are very powerful in selfrenewal,4 ^& S" k  n( P7 E" L
proliferation, and differentiation.+ f  b! c: X8 U! W, ]
Targeting on cancer stem cells, early diagnosis9 F( {! a( P6 v' p
for cancers might be achieved.
0 K1 \6 S0 g7 C$ GKey Words: Stem cell; Cancer stem cell; Cell differentiation;1 p. [) [7 a0 ?0 f
Tumorigenesis; Flow cytometer# m- A5 H% F2 j) k/ F" n
Qian B, Cai HQ, Feng J. Association of stem cells and
( J% f: ^5 R% h/ W! G" w% k0 M. Fcancer stem cells with tumorigenesis. Shijie Huaren
; g+ A1 z/ r) W, [9 LXiaohua Zazhi 2007;15(13):1526-1531: g0 Z9 y4 G/ W9 o

' C* S8 M: B. t5 J, `* M' J摘要
) E1 {, ?) J8 i肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则9 h! E" j: N  r1 J9 @3 o7 Q. w
由正常干细胞恶变形成. 正常干细胞的特有性: W1 q. b" e8 Z, h: q. C; t
状, 使其较成体细胞更易成为肿瘤发生的靶细
* A5 w, ]7 @$ Q6 J% [胞. 干细胞可能经基因突变、异常不对称分裂
" K% y7 }) L1 N9 X- e5 d4 F和细胞融合转化为肿瘤干细胞. 利用不同的蛋0 P) g. V- z7 P8 Q
白标志物或荧光探针, 通过流式细胞仪分选是
" @; k0 e! C& m' J6 |. G3 S+ r发现肿瘤干细胞的主要方法. 已证实的肿瘤干
& i* D3 `& h) i" i9 X& J! j细胞皆具有强大的自我更新和增殖能力, 以及
+ W1 m# T8 P% `: f细胞分化潜能. 针对肿瘤干细胞的检测和杀
) |. M* o& u/ l+ I9 x4 [伤, 可能为肿瘤早期诊断和治疗带来希望.
+ z+ W+ H" r8 u/ n" P) d8 C  u& `+ m关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;3 y+ P* k0 c# U
流式细胞仪
+ w- m* @) w9 e- F: o
6 O: u+ ?; W( K: g4 A附件为pdf全文，请大家支持一下 回复本贴就可以下载了! f* u+ ^6 Q/ O" j& R

4 A9 S: X' g  U# n4 M$ r2 R

jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

good m

yfancying

1# gone 0 X# \, L7 K0 t, `: ~
辛苦了

1234567

不错不错~

chenghoby

谢谢

hualin840518

xuyuhappyfish

感谢，感谢~~~

zhangqh

正在读这方面的文献