干细胞、肿瘤干细胞与肿瘤发生

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* S0 M! a* p5 {& l6 s4 R6 i钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
/ t( c5 @6 D% `* l究生院 北京市 100730
: f- G1 y- c# W6 q; u2 T通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学8 q' |0 j; Z. b
科学院中国协和医科大学中日临床研究所. qianbo79@163.com( [+ S6 L: P: q2 r: b. A
电话: 010-84206005 传真: 010-64206643) J- V* @! J' Q, I1 G1 N
收稿日期: 2007-03-17 接受日期: 2007-04-254 I* g% @9 b1 p. G; Q( y
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Association of stem cells/ O0 b8 l2 n, _$ U
and cancer stem cells with
  o' L- C  _+ m% [1 [tumorigenesis0 d. C5 e! n0 [
Bo Qian, Han-Qing Cai, Jie Feng9 e; w7 y" N5 R! q: ^& }& P
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
3 S6 Z& d' b6 a9 C/ O% ]Peking Union Medical College, Chinese Academy of Medical
) T7 C# N1 {  e! a8 HSciences, Beijing 100730, China
; I  s8 x8 T" mCorrespondence to: Bo Qian, China-Japan Clinical Research
5 n5 F. R3 Q1 ZInstitute, Peking Union Medical College, Chinese8 ]- k+ `6 y5 m! |6 X5 B
Academy of Medical Sciences, 2 Yinghua East Street, Beijing! {" H1 o% ^9 `% j) G0 p
100029, China. qianbo79@163.com& i* K5 R3 Y+ h
Received: 2007-03-17 Accepted: 2007-04-25
6 {; a! W+ [8 X1 S. T  mAbstract
/ E6 |- S' v' K. e" u# _6 oThe research on cancer stem cells is a new hot8 G" C) z- h! n4 D: x) @, ?
spot in at present. The hypothesis indicates
/ a$ X' C  G% b; S, ]" Mcancer stem cells, which were possibly the origin
. y' A' ~% p" U# A9 ?of the cancer, come from normal stem cells. For. k3 f% {# Z* A9 L3 t, I# U) F
their special characters, normal stem cells can
" E( y9 E9 e. Q7 `8 K2 C$ {% R! T* Qdifferentiate into tumor cells more easily than% ?$ m: k5 I9 A- e; P
adult cells. Stem cells transform into malignant0 @8 m+ w" x7 y
cancer stem cells possibly because of gene
6 \- O3 d% s+ M) s7 zmutation, abnormal asymmetry and cell fusion./ g" y, ?; p% q4 a5 ~4 w
It is a main method to obtain cancer stem cells by) W# l) I% i8 ]
flow cytometer using different protein markers
& J& B6 ?2 x/ x4 s( X1 gand fluorescent probes. It is demonstrated that( c! W( n, f' r" t+ h! l& p: b
cancer stem cells are very powerful in selfrenewal,; I+ z  T; F- C, Z0 O9 m
proliferation, and differentiation.4 w: c7 p. ]3 T, k2 x
Targeting on cancer stem cells, early diagnosis
% \" N8 C, n9 d' }6 ofor cancers might be achieved.
. O* i& I: a, L. X) xKey Words: Stem cell; Cancer stem cell; Cell differentiation;
+ e3 Y3 J0 L2 RTumorigenesis; Flow cytometer
) @9 |; S/ C' e4 \Qian B, Cai HQ, Feng J. Association of stem cells and
' h, A0 ~9 E. Q9 g! d7 f; dcancer stem cells with tumorigenesis. Shijie Huaren
- f7 h0 ]/ ?6 f) PXiaohua Zazhi 2007;15(13):1526-1531
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摘要7 S8 {. ^, h- j  f+ j
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则/ b! p: V/ g: j2 J
由正常干细胞恶变形成. 正常干细胞的特有性
3 Q+ p, q3 F" @. v+ I状, 使其较成体细胞更易成为肿瘤发生的靶细: @" w" S' p; D2 j3 F1 w
胞. 干细胞可能经基因突变、异常不对称分裂
4 X/ M2 n1 O" s& ?和细胞融合转化为肿瘤干细胞. 利用不同的蛋2 P0 u" x- c. b2 v! N
白标志物或荧光探针, 通过流式细胞仪分选是8 ^+ m0 W8 C* T% T
发现肿瘤干细胞的主要方法. 已证实的肿瘤干
2 x* o; D5 S, l  }细胞皆具有强大的自我更新和增殖能力, 以及4 q# {" R3 }( m# ?' F# \& H1 A
细胞分化潜能. 针对肿瘤干细胞的检测和杀
+ V+ D: Q1 @2 ^2 ?) ~伤, 可能为肿瘤早期诊断和治疗带来希望.; H3 F; i( ~! v, h9 y; i  C7 `% ~% ]
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
. O) E( n1 q, f7 E流式细胞仪0 G8 Z6 r: D: f/ k5 Z! X  t

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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