干细胞、肿瘤干细胞与肿瘤发生

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6 [$ b; l: a# t* M钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研- x1 m) R( r" j' }+ J
究生院 北京市 100730
$ I+ c' j/ t3 R! W通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
8 a; D- V- i2 w* J, k科学院中国协和医科大学中日临床研究所. qianbo79@163.com3 [6 ~) [" T* Y5 ~; Y* ~
电话: 010-84206005 传真: 010-64206643: m7 `; E5 C! Z- ~9 j8 g* d- N
收稿日期: 2007-03-17 接受日期: 2007-04-25
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3 G( J$ P% L' u3 YAssociation of stem cells( z7 K, Z- g$ ]3 V
and cancer stem cells with4 j0 j" g' s$ q2 @# c: l/ G0 g; B
tumorigenesis9 v8 K: J  I" B0 g/ n, d$ p3 M
Bo Qian, Han-Qing Cai, Jie Feng1 F' ?/ ^  J! g1 G$ }
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
; H" g! o% `% Q* C9 qPeking Union Medical College, Chinese Academy of Medical8 |8 j4 a" L, B  G
Sciences, Beijing 100730, China9 f; ?+ P; k* k/ x" P' ?# ~" w; F2 q
Correspondence to: Bo Qian, China-Japan Clinical Research
9 l* Q9 p4 U3 T' @; ^Institute, Peking Union Medical College, Chinese
/ u" }0 _& n& Q  z8 ^( QAcademy of Medical Sciences, 2 Yinghua East Street, Beijing
/ |3 J5 s" a/ f3 A  S100029, China. qianbo79@163.com
4 m. E, d" h8 u9 _- w1 C0 _* aReceived: 2007-03-17 Accepted: 2007-04-25
3 p8 h9 ^# [% |: O* j" AAbstract5 K' O, R6 p! F
The research on cancer stem cells is a new hot
% J  v) T; m, x+ j4 m% J) j: Nspot in at present. The hypothesis indicates* Z7 O8 ^+ O! H. ~/ \# |; U2 s
cancer stem cells, which were possibly the origin8 l+ G% T4 ~) J* m, ?; S$ \  |
of the cancer, come from normal stem cells. For. n  ~5 v- C3 J' E% g
their special characters, normal stem cells can5 I' }  L0 v3 R. k- c# q
differentiate into tumor cells more easily than
, w' Z" m& H& u+ U8 cadult cells. Stem cells transform into malignant
& m4 y, u; c' h1 Y, i8 ccancer stem cells possibly because of gene8 r9 q% R% H" k" M$ \4 v
mutation, abnormal asymmetry and cell fusion.
& [, L0 w; U' {$ N  i6 F% t. W1 \6 _It is a main method to obtain cancer stem cells by
5 f( i  I: ]: i; \7 \9 T- xflow cytometer using different protein markers5 o3 c: M' T+ B! ?( x$ z$ V
and fluorescent probes. It is demonstrated that
3 n0 ~% c, @7 p2 H1 `% M" L: W: jcancer stem cells are very powerful in selfrenewal,6 {3 c- ]3 @( R# r" S9 j
proliferation, and differentiation.
. U: ~, C8 Y+ d/ P, g+ |1 vTargeting on cancer stem cells, early diagnosis$ }$ Z9 Y, F6 E% _
for cancers might be achieved.
: H" I; w) ]* @3 ^; ZKey Words: Stem cell; Cancer stem cell; Cell differentiation;* |7 Y9 m7 Q- B* `
Tumorigenesis; Flow cytometer
! f! U( O( v0 I$ g0 i# Y5 |) ^6 aQian B, Cai HQ, Feng J. Association of stem cells and
5 t5 c, \0 L& e. v8 fcancer stem cells with tumorigenesis. Shijie Huaren
+ J8 A4 x/ a* i* s7 ~5 s/ O( H( HXiaohua Zazhi 2007;15(13):1526-1531
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8 _, N! B$ N5 y: Y, ~3 ]% H摘要
% B% w2 Q0 x% b8 @/ h3 _1 R+ B肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
$ L; D0 @, n; u" `( G5 K; }" [0 U由正常干细胞恶变形成. 正常干细胞的特有性
  K+ n+ `+ O$ V5 G# r状, 使其较成体细胞更易成为肿瘤发生的靶细# Y( Q# j0 j& U! ?% m0 @; M
胞. 干细胞可能经基因突变、异常不对称分裂
% E: ]3 P1 n$ J! }和细胞融合转化为肿瘤干细胞. 利用不同的蛋2 a- J4 ?0 f) ~5 }
白标志物或荧光探针, 通过流式细胞仪分选是# c8 s. d9 ^$ k* y4 n4 N
发现肿瘤干细胞的主要方法. 已证实的肿瘤干
2 e! j4 h( {7 j- h* R细胞皆具有强大的自我更新和增殖能力, 以及6 Y6 M2 l; t$ D5 }; h( o( l; U! l
细胞分化潜能. 针对肿瘤干细胞的检测和杀- x- P% t8 K" p. M0 i
伤, 可能为肿瘤早期诊断和治疗带来希望.  Y2 Z( n1 G* _6 H+ l! a, A
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
2 I4 }0 K' @  F! [1 m流式细胞仪
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* `) F* A" z" [; }, _( @' ]附件为pdf全文，请大家支持一下 回复本贴就可以下载了
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jitianxing7021

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