干细胞、肿瘤干细胞与肿瘤发生

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* Z8 g$ Q" Y0 C1 c钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
2 V. P  C5 ^4 B% v: T' k究生院 北京市 100730
0 r: V4 i0 e  B0 U% E: I" m- r通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学0 i4 x* u0 Q; g$ T' ]; w4 G& v
科学院中国协和医科大学中日临床研究所. qianbo79@163.com. [+ I9 ?/ c% [7 A, A: `2 V" ^' f
电话: 010-84206005 传真: 010-64206643
4 _) |7 `3 ?  s( ]2 {; O收稿日期: 2007-03-17 接受日期: 2007-04-25" S5 ]7 z: m7 Y  g6 {
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Association of stem cells) I) b: m! G1 b  f  U' @% c) k
and cancer stem cells with  ?& s7 K5 x( O0 e" l; n
tumorigenesis0 q5 Y+ b7 }% l5 F
Bo Qian, Han-Qing Cai, Jie Feng
7 R. y8 Y9 b% @: z6 I) _+ Q4 y& A7 n  uBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
; r" J( C# q3 ~* MPeking Union Medical College, Chinese Academy of Medical% l% W/ q& M  y  Y2 ]" @! \
Sciences, Beijing 100730, China
% I' w+ R5 H, pCorrespondence to: Bo Qian, China-Japan Clinical Research5 A' y6 U2 N% S5 Q5 A
Institute, Peking Union Medical College, Chinese2 f; u: q& g4 S2 a
Academy of Medical Sciences, 2 Yinghua East Street, Beijing. A" G4 ^, L* a0 H
100029, China. qianbo79@163.com
& J( H: X5 Z6 I0 q  w* R! mReceived: 2007-03-17 Accepted: 2007-04-25
' B( k* Q9 ?) j* s8 @2 PAbstract- V+ S# H0 l" t) Z9 x7 L, H
The research on cancer stem cells is a new hot
$ Q" \1 i2 S5 y- j  F; pspot in at present. The hypothesis indicates
" a' a9 H% A( ?( A- U% H# n* @2 Rcancer stem cells, which were possibly the origin
0 k) H* |$ }( g8 Rof the cancer, come from normal stem cells. For
$ i0 ^! e3 N" utheir special characters, normal stem cells can6 [# H+ a% k; m
differentiate into tumor cells more easily than
/ T' z' r) f& N4 C  kadult cells. Stem cells transform into malignant
! ?) J4 ?! Z/ d& ccancer stem cells possibly because of gene+ C6 b' d; }3 p$ k. \- }
mutation, abnormal asymmetry and cell fusion.
) j/ s$ R- b: c0 z3 iIt is a main method to obtain cancer stem cells by) Q* c' j5 }) a. y
flow cytometer using different protein markers+ J' _, Z2 {( v6 `2 m2 n: [- J1 h
and fluorescent probes. It is demonstrated that
* ?* T" K6 |1 E( ?- Wcancer stem cells are very powerful in selfrenewal,* ^& j; {" ]; u
proliferation, and differentiation.
5 R4 F+ b  E$ b8 ~1 E2 }% `Targeting on cancer stem cells, early diagnosis
3 {5 l; L; }# _% ?; j- Kfor cancers might be achieved.& A7 Q  T* z/ @2 j0 p' h
Key Words: Stem cell; Cancer stem cell; Cell differentiation;
/ o: `  S2 Y8 w0 \: KTumorigenesis; Flow cytometer9 g! e+ Y* O8 Q; ~
Qian B, Cai HQ, Feng J. Association of stem cells and
" E6 i! e- ^6 W& m: Pcancer stem cells with tumorigenesis. Shijie Huaren# f7 z6 [2 t; V0 x7 n
Xiaohua Zazhi 2007;15(13):1526-15318 C5 B/ ?; r/ M4 u4 y

1 c7 W( N3 l4 g! K摘要2 T4 @, W4 O7 V( s0 w2 f& x
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
2 J5 E, s- t  F由正常干细胞恶变形成. 正常干细胞的特有性$ N* O8 R7 X$ n$ t$ k7 \
状, 使其较成体细胞更易成为肿瘤发生的靶细% G9 m7 x# _4 e1 O$ p( h+ B' ?$ @
胞. 干细胞可能经基因突变、异常不对称分裂
* G2 i6 q6 w- J+ I和细胞融合转化为肿瘤干细胞. 利用不同的蛋
0 w- n5 x1 O* ]: k+ N, O白标志物或荧光探针, 通过流式细胞仪分选是
& P8 j* j9 q* c3 P$ E- b" n! m6 M/ S发现肿瘤干细胞的主要方法. 已证实的肿瘤干
1 a  s* `6 _; v4 b细胞皆具有强大的自我更新和增殖能力, 以及
, A( ^" w$ Q: y) \细胞分化潜能. 针对肿瘤干细胞的检测和杀
+ Z  c. }, R; J$ ], F伤, 可能为肿瘤早期诊断和治疗带来希望.
) f6 S6 F4 p( y' {3 t2 R关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;* d$ u2 n1 S2 v4 l0 w
流式细胞仪
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1 K) M: p, y" B0 g* G7 ]) |( i附件为pdf全文，请大家支持一下 回复本贴就可以下载了
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

good m

yfancying

1# gone : \/ ]- {5 }2 `* h* y+ S
辛苦了

1234567

不错不错~

chenghoby

谢谢

hualin840518

xuyuhappyfish

感谢，感谢~~~

zhangqh

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