干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
  |& l( }- {( P9 Q究生院 北京市 100730
5 H+ f' `) P4 W: g; S通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学5 N6 a: X7 Q- A) P3 k  W7 b) z
科学院中国协和医科大学中日临床研究所. qianbo79@163.com
2 \( K( D6 \0 G9 @; k电话: 010-84206005 传真: 010-64206643
# C" B0 e/ p5 V收稿日期: 2007-03-17 接受日期: 2007-04-25
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. x3 o: h6 ^7 B. d, i7 IAssociation of stem cells+ J: \* s1 p% c+ B' y4 o
and cancer stem cells with- g! j4 ^" E- r
tumorigenesis
5 _$ ^( Y% S( R4 v7 O( sBo Qian, Han-Qing Cai, Jie Feng
  i* h. Q/ f) V- h7 oBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
$ D) b/ }! D7 a2 r0 c/ R% w8 }Peking Union Medical College, Chinese Academy of Medical* d; R5 K2 K. w1 ?9 n
Sciences, Beijing 100730, China; O$ q- f, O" O7 j
Correspondence to: Bo Qian, China-Japan Clinical Research
# ~  `) ]9 t7 b- t% k4 Z7 H+ wInstitute, Peking Union Medical College, Chinese# @. E/ t# L) ^6 X$ Z. b
Academy of Medical Sciences, 2 Yinghua East Street, Beijing. r* y3 e9 [0 h
100029, China. qianbo79@163.com
* o/ ^9 G4 V& e& t3 l7 W) w& N" VReceived: 2007-03-17 Accepted: 2007-04-258 f+ d- i. m( b0 \+ [, u
Abstract
( `, w4 ^) y& ~) x* ~( Q) E" aThe research on cancer stem cells is a new hot4 |9 p5 ^5 T' }) H2 v
spot in at present. The hypothesis indicates0 [: J* i8 f# a( N9 x3 \
cancer stem cells, which were possibly the origin
1 q5 {( w6 T  U0 w( i1 u$ {5 C; H' V  Wof the cancer, come from normal stem cells. For
& s' R1 |, i- x% htheir special characters, normal stem cells can4 y& s. U; C+ z: ?
differentiate into tumor cells more easily than
- i* Z+ Y: P6 ?% ]* I8 e7 V6 ]0 u$ {adult cells. Stem cells transform into malignant
5 m9 ~0 z: L+ Acancer stem cells possibly because of gene( S4 F2 q- W2 ]
mutation, abnormal asymmetry and cell fusion.
7 C9 O; g: @$ T( b; i! KIt is a main method to obtain cancer stem cells by- A3 }! s& d; D$ M* A
flow cytometer using different protein markers, Z" ~: X! @9 t3 `" R; N: a* I* ~
and fluorescent probes. It is demonstrated that9 d9 L" r. r5 u8 K- t; ]
cancer stem cells are very powerful in selfrenewal,/ ^3 \% f6 C4 X# Z- K& X* {
proliferation, and differentiation./ s/ N3 r- |) S
Targeting on cancer stem cells, early diagnosis9 e: a7 L( M) Z9 F4 v& Y
for cancers might be achieved.
, D! ~; J1 H% B. d1 f* N* l# h9 L. J: `Key Words: Stem cell; Cancer stem cell; Cell differentiation;
- ^2 M$ ~1 v7 K* Z( }; G. {Tumorigenesis; Flow cytometer
, c+ K; T; a5 }0 E; R9 lQian B, Cai HQ, Feng J. Association of stem cells and
6 |' ]' W9 i  x4 C* p! K$ ycancer stem cells with tumorigenesis. Shijie Huaren
& R# S" X% l$ \: C' |- {Xiaohua Zazhi 2007;15(13):1526-1531# u8 x6 d: w! K1 T
+ T2 [! i' X  V# m1 k* N
摘要
" T2 Y" U8 @& J/ c! ~  z肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
2 ?7 ~: B0 E% u. O4 t& f5 {由正常干细胞恶变形成. 正常干细胞的特有性
* Z( U$ i8 |* Z9 D! J状, 使其较成体细胞更易成为肿瘤发生的靶细; C* y- g3 M% ]' i
胞. 干细胞可能经基因突变、异常不对称分裂
9 w& g# U+ U" q  l和细胞融合转化为肿瘤干细胞. 利用不同的蛋
+ Z# H2 s) f6 Q6 y) }& z1 x白标志物或荧光探针, 通过流式细胞仪分选是
' F4 L8 `2 I5 i发现肿瘤干细胞的主要方法. 已证实的肿瘤干8 l0 x8 S* r0 g" ^! F& ^+ D9 Q
细胞皆具有强大的自我更新和增殖能力, 以及
* a  m: L. f' P) G/ D细胞分化潜能. 针对肿瘤干细胞的检测和杀
7 D7 w& D" V/ k5 |, c& g+ m伤, 可能为肿瘤早期诊断和治疗带来希望.
% j* K4 t9 p* _2 T1 b0 f关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;- E) \* q, u* Y$ V
流式细胞仪: f: D7 R+ _8 k  I$ j

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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