干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研( ^$ [4 h4 S; a! V
究生院 北京市 100730
9 Y0 b* M( f1 I* _5 @通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学+ L5 x1 Q: b7 A+ Q4 S7 @/ H5 s
科学院中国协和医科大学中日临床研究所. qianbo79@163.com# y; F% G1 Y* N1 e- l# M; c) t
电话: 010-84206005 传真: 010-64206643. r# ~$ a& F5 N, J& a+ K# q3 l4 Q3 @
收稿日期: 2007-03-17 接受日期: 2007-04-25
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Association of stem cells
6 ?( S0 _% p* @& n2 @8 A# e. ~and cancer stem cells with2 v% s( G1 k  x0 V
tumorigenesis0 U7 G+ [5 t- R* p5 q( X3 Y
Bo Qian, Han-Qing Cai, Jie Feng
- r' W" `% d8 i: @; nBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
: e" \4 f; W& e3 H/ ]Peking Union Medical College, Chinese Academy of Medical: L7 C/ u- Q& u) ~, _) @; E
Sciences, Beijing 100730, China0 J' ]/ X% B/ }
Correspondence to: Bo Qian, China-Japan Clinical Research0 @. A% }' R  L; @) \! F
Institute, Peking Union Medical College, Chinese
' K/ M9 R  S5 [: n, YAcademy of Medical Sciences, 2 Yinghua East Street, Beijing' y* r) j# Y/ c0 \" F
100029, China. qianbo79@163.com) T5 }, j. P* |. w4 G2 ]" P# H
Received: 2007-03-17 Accepted: 2007-04-25
7 y. q  g7 m7 a# G+ s9 o. ?Abstract" A, u1 v" V& p; ?& i* U$ [
The research on cancer stem cells is a new hot, b0 Y9 R) x) \& \! e* [4 d
spot in at present. The hypothesis indicates
  D5 i, T3 r4 S; Ncancer stem cells, which were possibly the origin
% y* j2 I& M& d, Kof the cancer, come from normal stem cells. For* D, V! `2 @6 F, a2 p. W7 M- a& a: u
their special characters, normal stem cells can. K3 H+ H) `8 W6 B- G  v$ q0 c
differentiate into tumor cells more easily than
4 A7 {6 u2 ], x; \: dadult cells. Stem cells transform into malignant
& f- {/ @/ K' A. h& `+ [* [. ]5 `2 Wcancer stem cells possibly because of gene) @/ j2 U( ~1 Y: w2 L
mutation, abnormal asymmetry and cell fusion.4 R  S# t" p$ d$ n7 M) d& f6 D
It is a main method to obtain cancer stem cells by
: F1 v( f) J' `7 j/ U- i9 J3 qflow cytometer using different protein markers
2 p6 o& f  r- O( u- e8 ?* `and fluorescent probes. It is demonstrated that+ X* b2 X7 F; z) h
cancer stem cells are very powerful in selfrenewal,7 C. F; ?# \* ^
proliferation, and differentiation.
% g# y* Q1 {6 T) ~: kTargeting on cancer stem cells, early diagnosis* Z2 r2 W3 j2 e6 b2 g1 B  P
for cancers might be achieved.% ^: \$ a- b! {" U% y, h$ T7 X+ u
Key Words: Stem cell; Cancer stem cell; Cell differentiation;
1 n6 O0 N9 m3 p% U) F2 g0 T8 wTumorigenesis; Flow cytometer
  z- a* P* ]; O) k$ u" h  nQian B, Cai HQ, Feng J. Association of stem cells and
/ X  y! r% E- J+ H) vcancer stem cells with tumorigenesis. Shijie Huaren
3 C1 j* f+ W; AXiaohua Zazhi 2007;15(13):1526-1531
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摘要
0 ?8 j: y* O5 u, U肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
% |- |( I# p9 Q; d5 U! v由正常干细胞恶变形成. 正常干细胞的特有性( m7 v  Y* b3 ]
状, 使其较成体细胞更易成为肿瘤发生的靶细
# K* y: p  P4 l% B: c! C胞. 干细胞可能经基因突变、异常不对称分裂8 {  n( T( h! ?) l2 d" E3 I$ x+ P8 V
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
- R7 {6 i& l* d) V3 r* j; U6 }6 ?9 `白标志物或荧光探针, 通过流式细胞仪分选是* t5 Y! _# H( g. Q( \
发现肿瘤干细胞的主要方法. 已证实的肿瘤干
6 c3 O; h! {5 \2 g细胞皆具有强大的自我更新和增殖能力, 以及
2 w, G/ l3 G$ ]细胞分化潜能. 针对肿瘤干细胞的检测和杀0 J& n3 ~2 a3 w' t
伤, 可能为肿瘤早期诊断和治疗带来希望.1 g0 M/ t& k! F4 @- p- L4 K1 r
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;' x" S& E$ a% P3 g/ _9 @
流式细胞仪7 I% r6 \# z* B3 y# [

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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