干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研! ^5 U4 R& P+ j3 s+ d  f! f; q
究生院 北京市 100730
" n7 U! u$ Q& A# ?( l7 q  N通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学2 ^* j; T4 r% x7 H. A# s7 C. Y
科学院中国协和医科大学中日临床研究所. qianbo79@163.com. S5 ]8 Z9 a4 n/ M( H9 u% j
电话: 010-84206005 传真: 010-642066433 t. V/ [! \& e/ g) f
收稿日期: 2007-03-17 接受日期: 2007-04-25
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' W" s* g; q8 ^) h& u& I- UAssociation of stem cells
! P; j7 T3 b2 b( B% c, x: {5 Pand cancer stem cells with8 I; d- [/ O/ w/ T
tumorigenesis
3 P$ Y% Z" [, {: ~Bo Qian, Han-Qing Cai, Jie Feng5 E0 Z7 L7 k1 C3 `
Bo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of7 Z! O) I) F  }/ V. e0 N4 ~  o: Z5 D
Peking Union Medical College, Chinese Academy of Medical# W5 A  W( @6 _( j$ B8 ]. e8 g
Sciences, Beijing 100730, China
7 W( r8 a: t! o" S; _. `Correspondence to: Bo Qian, China-Japan Clinical Research! w: f* ^) u# J$ a8 o9 C
Institute, Peking Union Medical College, Chinese* |) s! U8 ^* q4 g
Academy of Medical Sciences, 2 Yinghua East Street, Beijing6 J' {0 H7 `9 p. G5 d
100029, China. qianbo79@163.com+ O7 \3 W$ L' @0 [: F" G  a
Received: 2007-03-17 Accepted: 2007-04-25
5 Z3 z" L6 R) C8 ^  a: x# z9 oAbstract9 L* T: E5 \* N* @; X2 R3 X7 `) h; c
The research on cancer stem cells is a new hot
2 v- I" w2 N) U% tspot in at present. The hypothesis indicates
8 F7 e! x) f8 `+ Acancer stem cells, which were possibly the origin( e3 D( |8 m: H. W0 h: O# z
of the cancer, come from normal stem cells. For
9 _3 N$ r& m- U' ctheir special characters, normal stem cells can
+ E! i2 K8 W% i4 r* J* J8 R5 G! Hdifferentiate into tumor cells more easily than0 ^: J$ {8 S0 z, L) j8 V# i8 H8 ]
adult cells. Stem cells transform into malignant
0 q) @" c8 t. `+ scancer stem cells possibly because of gene
. N* a# Q: U1 ^% Zmutation, abnormal asymmetry and cell fusion.* r3 ?4 S3 w" z! l
It is a main method to obtain cancer stem cells by+ E4 H# d/ H$ }9 W- R
flow cytometer using different protein markers" _& O+ k! G6 @' U) D
and fluorescent probes. It is demonstrated that
& u- N5 J/ f1 e2 P- G( D* N, C5 Q8 dcancer stem cells are very powerful in selfrenewal,. c; ~3 W3 ?+ O/ C' c7 z2 f+ a8 X
proliferation, and differentiation.; B: ]) e# K6 n3 p
Targeting on cancer stem cells, early diagnosis5 \9 K/ b" N3 a/ P% C, @
for cancers might be achieved.1 t2 j" c5 S9 u
Key Words: Stem cell; Cancer stem cell; Cell differentiation;
6 f3 ~. o- m! z+ T. oTumorigenesis; Flow cytometer
* d* U/ l9 c5 i9 dQian B, Cai HQ, Feng J. Association of stem cells and" t# _( J" q8 n3 b
cancer stem cells with tumorigenesis. Shijie Huaren
0 j9 u2 H& o3 c; \0 ^2 zXiaohua Zazhi 2007;15(13):1526-1531
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. s7 o- H- p& L/ M摘要1 ?' V3 h% o$ H9 A, K
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
# c; I. g* w: J+ T9 f  V* v; h1 V由正常干细胞恶变形成. 正常干细胞的特有性. S; s) J3 G7 Y, Y' n/ n
状, 使其较成体细胞更易成为肿瘤发生的靶细4 m  O1 @: Y" X( \" d4 g/ ~+ s( C1 o- @
胞. 干细胞可能经基因突变、异常不对称分裂6 ^7 V* [, j' ^+ Q% U' ^
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
2 w. B3 j; X& j( y* o白标志物或荧光探针, 通过流式细胞仪分选是# i6 d8 Q5 ~# K2 q9 C" `2 p; W
发现肿瘤干细胞的主要方法. 已证实的肿瘤干
  Z* I( M& o- w) }2 R) R细胞皆具有强大的自我更新和增殖能力, 以及
% B- C( D+ K7 ]+ e细胞分化潜能. 针对肿瘤干细胞的检测和杀
2 b  |% y7 E0 w; @! }) X# }+ w; X伤, 可能为肿瘤早期诊断和治疗带来希望.( Z- r5 u! ]& C9 R- H
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;+ T) m# `! M# B" I5 M6 K( _
流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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