干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
- z! ]( C, x8 E9 @5 w7 i  E( C8 Q9 C. [究生院 北京市 100730
$ q2 v* G* Z3 }1 x3 `+ N通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学* Q, l6 z/ B: g# ?
科学院中国协和医科大学中日临床研究所. qianbo79@163.com! b' b! {1 T8 v9 b2 r: `6 r/ ]1 b
电话: 010-84206005 传真: 010-64206643- o4 R0 p1 c! n  v; O
收稿日期: 2007-03-17 接受日期: 2007-04-252 g1 r" F$ p) l# ]$ M
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Association of stem cells: a2 O! w3 k, ]2 b( Y
and cancer stem cells with
2 P- J# W% h: b; R% Ztumorigenesis  o: e$ q" r4 G0 n/ [
Bo Qian, Han-Qing Cai, Jie Feng
8 e3 `( V5 d* Q0 S' e7 t3 IBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
7 U0 N5 ^* A8 G! Y* H# @2 nPeking Union Medical College, Chinese Academy of Medical& ?* t4 @  }2 R  p5 F% Z1 X
Sciences, Beijing 100730, China7 L2 s0 A7 a& q3 S: d  I
Correspondence to: Bo Qian, China-Japan Clinical Research5 f- x. ]  y9 M+ u! o! [
Institute, Peking Union Medical College, Chinese' u, O  f! j! z9 p
Academy of Medical Sciences, 2 Yinghua East Street, Beijing. I+ l( g+ Y9 G
100029, China. qianbo79@163.com8 a1 c! A  C% a' U5 X. l9 l
Received: 2007-03-17 Accepted: 2007-04-25
/ Z; a- H$ C/ tAbstract
2 D. |) g' }6 L( q8 ^The research on cancer stem cells is a new hot
; ^9 y9 m2 s8 g2 ~, Q; R1 Hspot in at present. The hypothesis indicates
% j) t* r4 z% e! Q% T. _  ?- jcancer stem cells, which were possibly the origin
- r2 g! `8 q+ [  U- [of the cancer, come from normal stem cells. For
# f: }' ^0 y) S* d2 _  L1 jtheir special characters, normal stem cells can1 M. y1 C% v) j
differentiate into tumor cells more easily than
6 c% y9 i7 z. t6 `5 |0 O' Yadult cells. Stem cells transform into malignant: `% `# I8 A) ], U( |9 f- b3 s
cancer stem cells possibly because of gene
  h) K2 x5 h% D' L' ~. i# W/ Ymutation, abnormal asymmetry and cell fusion." t; r9 ]+ M4 w
It is a main method to obtain cancer stem cells by- Z% t  f3 a  a/ _
flow cytometer using different protein markers. H6 o# Z: @! s# F
and fluorescent probes. It is demonstrated that
3 M4 q; v$ k5 }' K  w- A" v! m4 R1 ycancer stem cells are very powerful in selfrenewal,/ [1 x5 a% i: y7 _
proliferation, and differentiation.
6 Z- E- l) f9 Z4 LTargeting on cancer stem cells, early diagnosis
% w! M9 `% R9 I/ q  p" |for cancers might be achieved.& C  n3 p) {$ H: V
Key Words: Stem cell; Cancer stem cell; Cell differentiation;
/ W- ~$ E' O' l2 R5 V7 lTumorigenesis; Flow cytometer
/ Q7 x" |$ j3 T$ }5 [2 PQian B, Cai HQ, Feng J. Association of stem cells and
& W; D$ l  U2 }cancer stem cells with tumorigenesis. Shijie Huaren
" ^! S5 ?% E) ~- p1 @  xXiaohua Zazhi 2007;15(13):1526-1531
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+ E/ u8 i/ u% ]) D摘要
- i) O* I$ z8 C2 i0 k肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
# {' D" v/ n: n: u. x% i; M由正常干细胞恶变形成. 正常干细胞的特有性" R7 M( {& B2 s! K. O
状, 使其较成体细胞更易成为肿瘤发生的靶细
" p" |' K; r: ]胞. 干细胞可能经基因突变、异常不对称分裂! f( m) u" h2 @
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
8 g, Y; K( _6 ?6 _白标志物或荧光探针, 通过流式细胞仪分选是
& z$ w, I/ B3 N发现肿瘤干细胞的主要方法. 已证实的肿瘤干  f, W! z  D" l2 I& \4 R# _- J! I
细胞皆具有强大的自我更新和增殖能力, 以及
+ ~8 g  h: N7 y) ?8 Z, L细胞分化潜能. 针对肿瘤干细胞的检测和杀) H2 S( z! [; v9 C2 ~; `
伤, 可能为肿瘤早期诊断和治疗带来希望.$ g, A4 s3 i0 Q: s; J. A& \5 n  S
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
' j+ M0 Z0 W1 Z( U: G流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

good m

yfancying

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辛苦了

1234567

不错不错~

chenghoby

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xuyuhappyfish

感谢，感谢~~~

zhangqh

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