干细胞、肿瘤干细胞与肿瘤发生

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6 i5 v9 t% |9 f; `5 }  ?钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研  h. |$ P6 a' V4 B, r. s- z
究生院 北京市 1007303 T& u$ S8 D: J5 _; \0 ~
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
1 Q8 D; T& E! }! m科学院中国协和医科大学中日临床研究所. qianbo79@163.com
: F1 ~6 [2 m/ a5 X/ x电话: 010-84206005 传真: 010-64206643
1 k6 a- F2 f2 G9 t收稿日期: 2007-03-17 接受日期: 2007-04-25, S6 p; i  \' C5 M* J0 e

" r0 g0 a; \8 x& w; J7 @$ _) s& LAssociation of stem cells
+ u% N  s2 s+ Q+ O! o3 V9 K, wand cancer stem cells with
8 A1 Z$ }( x. f$ htumorigenesis9 {5 O; G7 M0 L6 {1 I! W" J
Bo Qian, Han-Qing Cai, Jie Feng
  P" Z/ I. K: L" iBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of
; E$ a0 j6 _/ t. L- t8 \Peking Union Medical College, Chinese Academy of Medical
& t. B, x4 u/ S" |/ o4 S/ J6 L: aSciences, Beijing 100730, China( p- Q' r! d" s5 S  v
Correspondence to: Bo Qian, China-Japan Clinical Research( y9 H. C2 g: H. W  a! E5 X% h
Institute, Peking Union Medical College, Chinese0 {* |# r# _/ a4 `0 _
Academy of Medical Sciences, 2 Yinghua East Street, Beijing0 ]8 r% i0 k$ Q8 {' [
100029, China. qianbo79@163.com
" O, f# Z! Q  O( B. ^& b" BReceived: 2007-03-17 Accepted: 2007-04-25
; T+ ?7 V/ w  @& r& PAbstract; K* H9 ]4 \# N6 t, v) e
The research on cancer stem cells is a new hot
- \- u4 }8 w$ s+ Q, A7 \spot in at present. The hypothesis indicates
  S$ o8 F+ T: e' S# ^cancer stem cells, which were possibly the origin
& w" K$ ~9 j# aof the cancer, come from normal stem cells. For
2 D5 n6 b$ B1 F3 m3 t( stheir special characters, normal stem cells can8 Z/ j6 d7 s" K0 B7 |
differentiate into tumor cells more easily than, w: K2 D8 @( D+ p
adult cells. Stem cells transform into malignant9 j) ~5 }1 p# m6 ~+ Z; _
cancer stem cells possibly because of gene- K9 I% o9 a" {7 F5 f- J% K
mutation, abnormal asymmetry and cell fusion.
5 X( x7 |5 T& rIt is a main method to obtain cancer stem cells by
* z) g& O! P( r2 p3 V1 Oflow cytometer using different protein markers
, S% d: c+ D& e# P- _  E/ b5 i# hand fluorescent probes. It is demonstrated that
$ K- C7 {! m/ S/ B  j( mcancer stem cells are very powerful in selfrenewal,  B& U# s7 P5 |; D" |$ W
proliferation, and differentiation.' N. {" @4 ?$ d/ U* f' x- d
Targeting on cancer stem cells, early diagnosis
7 R- M2 F% F3 j; j- afor cancers might be achieved.
7 f! Y4 f% R$ c2 q# J4 j8 aKey Words: Stem cell; Cancer stem cell; Cell differentiation;# s+ L" z9 _$ F- g0 `, s! L$ X$ X
Tumorigenesis; Flow cytometer
( O' `( F- ?) v: m6 RQian B, Cai HQ, Feng J. Association of stem cells and
2 k8 _% O2 N3 D& s5 U1 ycancer stem cells with tumorigenesis. Shijie Huaren
9 C, L" W' T7 x7 w$ s3 D! FXiaohua Zazhi 2007;15(13):1526-1531
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摘要
, Y. S: w! s+ H, N% @肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则5 S/ Q& g0 X. s& z4 F
由正常干细胞恶变形成. 正常干细胞的特有性( ]' o$ \8 [' y2 d
状, 使其较成体细胞更易成为肿瘤发生的靶细2 Q) B- ]7 y& G$ i
胞. 干细胞可能经基因突变、异常不对称分裂4 [- G6 O/ D7 X9 Q
和细胞融合转化为肿瘤干细胞. 利用不同的蛋6 f/ |7 I/ S% W* J7 P3 X
白标志物或荧光探针, 通过流式细胞仪分选是
7 e3 Y" ]: w+ @: b发现肿瘤干细胞的主要方法. 已证实的肿瘤干4 n: h6 p3 K! Z4 H& t
细胞皆具有强大的自我更新和增殖能力, 以及+ d1 G+ F9 A6 Z$ _) d0 d/ d
细胞分化潜能. 针对肿瘤干细胞的检测和杀
7 Z2 I" p8 t0 f. C* K7 X伤, 可能为肿瘤早期诊断和治疗带来希望.
  s+ b+ X! V3 m# n0 I/ Z关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;' B. A% l1 e$ Q8 v3 ~" r7 d
流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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