干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研, I4 r+ ?3 m; K
究生院 北京市 100730$ U8 b' G+ ]+ m+ B7 A
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
( d* d/ b" @- T' v. T科学院中国协和医科大学中日临床研究所. qianbo79@163.com
- e3 N6 g4 f+ I, W8 f( o. q电话: 010-84206005 传真: 010-64206643/ q; Z: X5 }3 z+ H- ~! k& }2 u1 A
收稿日期: 2007-03-17 接受日期: 2007-04-25# w+ w0 e+ h- c2 I- O

+ b$ c  h: a' G; I( \$ ?Association of stem cells1 X" N# u. |7 g0 y% S9 ?
and cancer stem cells with$ b5 Q5 j. d6 \4 v. x# d6 a" y* Z3 P
tumorigenesis8 g+ r- X9 K. v+ f( W- W. H
Bo Qian, Han-Qing Cai, Jie Feng
8 H+ }8 x8 S8 JBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of2 l6 g6 [  x" q1 F. h+ g) j* L
Peking Union Medical College, Chinese Academy of Medical
$ R. o1 |4 C8 t5 C- Q, @Sciences, Beijing 100730, China; X8 ~: s, O7 B( O; D
Correspondence to: Bo Qian, China-Japan Clinical Research3 R! K! `6 J0 J# T9 E
Institute, Peking Union Medical College, Chinese/ b, d6 E* c# O% P7 M
Academy of Medical Sciences, 2 Yinghua East Street, Beijing/ T& r! Z# T( E# v  _" N
100029, China. qianbo79@163.com0 Y% y0 o" D+ N
Received: 2007-03-17 Accepted: 2007-04-251 o5 E( {6 Z3 l2 Y: ?
Abstract
, X& q, q4 H' h  v' [The research on cancer stem cells is a new hot* c, D+ m4 C7 L8 k, q+ g+ ]
spot in at present. The hypothesis indicates
% Q; g- j! [  w4 P8 w; C$ Bcancer stem cells, which were possibly the origin$ o! \5 x" U4 Z! |: o+ S
of the cancer, come from normal stem cells. For& a  T( S+ E& }( P, y5 k
their special characters, normal stem cells can
" {; r0 Y4 E4 f  Hdifferentiate into tumor cells more easily than
& P8 a% _# [) N8 kadult cells. Stem cells transform into malignant
# A2 ]! P% J$ E' G% Hcancer stem cells possibly because of gene
' L$ @* O% B4 amutation, abnormal asymmetry and cell fusion.$ X' }7 a0 P1 z, T% J
It is a main method to obtain cancer stem cells by0 F( x1 ^" V5 i& ^4 h6 w
flow cytometer using different protein markers
1 d7 X* d3 n! ~0 O( b: v1 nand fluorescent probes. It is demonstrated that
8 c' E  A5 F; [$ q. O2 Ocancer stem cells are very powerful in selfrenewal,
6 G$ \) D# ]3 ~4 Cproliferation, and differentiation.9 ^- }& V! X5 [- L7 n4 b$ w
Targeting on cancer stem cells, early diagnosis
9 {9 t1 D" S" s, Zfor cancers might be achieved.
. l0 v. D2 j& @- Y4 c1 V8 e1 RKey Words: Stem cell; Cancer stem cell; Cell differentiation;) z' A* `! L- g& Y
Tumorigenesis; Flow cytometer
  O) f/ H( m6 @2 T4 d: EQian B, Cai HQ, Feng J. Association of stem cells and, r1 ?( c: ?" G- L) x, |/ j
cancer stem cells with tumorigenesis. Shijie Huaren4 @( J" i" o' j4 ]6 N9 t
Xiaohua Zazhi 2007;15(13):1526-1531& f0 Q$ c. X6 a  v( J
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摘要! f+ a! p8 C7 i$ V* a/ n
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
" Q& H# ~1 j# k! ~8 S' r. M由正常干细胞恶变形成. 正常干细胞的特有性
8 g0 ?* w0 P1 L* ^7 {状, 使其较成体细胞更易成为肿瘤发生的靶细
- z  j9 N1 }( b) t  r胞. 干细胞可能经基因突变、异常不对称分裂
6 Z: {6 h. ]4 m, ]7 g, B' Q/ k0 f9 u和细胞融合转化为肿瘤干细胞. 利用不同的蛋
/ E) t) v2 \6 Y* c3 Q# g; s1 U白标志物或荧光探针, 通过流式细胞仪分选是# R; m9 z/ }; i7 w9 a
发现肿瘤干细胞的主要方法. 已证实的肿瘤干
! O& M; O5 o1 v7 D细胞皆具有强大的自我更新和增殖能力, 以及
( U: F0 t- K! ~- q+ l; {细胞分化潜能. 针对肿瘤干细胞的检测和杀
( B' R. E1 ^% C  r2 @9 c伤, 可能为肿瘤早期诊断和治疗带来希望.$ a# k* r; |& r7 _/ H% [7 p) O$ D; p
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
3 N  ?" y" f6 H: N. D流式细胞仪
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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

ahmusht

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yfancying

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chenghoby

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xuyuhappyfish

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