干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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刘晓珑　李波
+ `8 u0 d' Y* p, B' y! n1 Q1 i. R* J　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文
) g$ m0 C+ i/ J' C( l3 h献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以, V4 k" Y+ q/ v+ t# W
分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床
  @/ b* F/ q4 O# a; D  k& |相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。
" A+ h  |; o* |* o; b6 M: {% b【关键词】　　干细胞　　再生医学　　肝脏
* J8 |  D2 _* x' n& K3 _中图分类号: Q 813　R65713　　文献标识码:A2 y- F1 d7 ~, _# \: e
DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU5 p( M& e" I7 ~4 |6 r0 u
X iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,3 s- I7 @; y: x) T2 X0 d- L" \/ |  r
610041, P. R. Ch ina. E 2m ail: g x lliu@126. com% T  |% D8 b7 b& R* E
Corresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn
" ]. u: `7 J% y+ s  R) _【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive$ a, w/ i) x1 u+ ^
t reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,6 H1 _$ s' _$ q, K7 @6 V9 M! z
adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere) _# ?7 V. l* ~: J+ Q7 c  T  B
extensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,
, `7 a- H5 K, D* v# _4 x9 W1 ?i. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell
+ B3 A! j% @( t* P- y( y1 Cfusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the
8 m2 l# W5 ~3 g, w% h# Fapp licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further( a8 K! z9 n2 C5 ?5 q7 w
studies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the/ n4 I9 P1 ]+ V0 Y
liver stem cell t ransp lantat ion.& b; M9 u. ]' M- M
【Key words】　　Stem cell　　Regenerat ive medicine　　L iver
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0 w& x* @4 B# `5 X& l+ s附件为pdf全文，感谢原创提供者 ，大家回复之后就可以下载了
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