干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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5 Z0 J  Q  q1 d刘晓珑　李波
2 L( m; a+ X* H+ [6 k　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文% b% N1 Z. @9 H
献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以2 h; v+ z1 D4 g5 `- z9 M
分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床
5 ~  s4 s1 ?7 D( t7 z3 b相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。& W/ D; I4 F3 m( m3 n) w
【关键词】　　干细胞　　再生医学　　肝脏5 C2 a& a. O' E4 X! v
中图分类号: Q 813　R65713　　文献标识码:A% T0 s6 {3 J* c3 ^( S
DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU5 a, t3 L( @# a
X iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,# r& _  h0 ]) V+ y- \5 q6 |) Z( j  O2 {. s
610041, P. R. Ch ina. E 2m ail: g x lliu@126. com
7 [$ r: G2 q5 t4 E# _0 B* G- R  jCorresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn9 f# |% d/ h/ l: {$ F  M
【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive! g) }4 d& I+ Q6 G9 X, j2 m+ f
t reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s," E! E& ~7 s4 E, r. Y9 m' i
adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere4 D* V2 ^6 N1 u0 w- D/ E
extensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,- G  m- c( @2 |, F; T5 Z
i. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell
/ Y' p+ {7 W! Q1 t  U5 y) ffusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the
1 V: y6 a7 P/ `& n$ p* F6 s; A$ sapp licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further+ T) L" z  L5 d5 L- }4 C$ C
studies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the/ [* ~4 D' ~, W4 Q9 g
liver stem cell t ransp lantat ion.8 W6 S2 x8 ^, k. |
【Key words】　　Stem cell　　Regenerat ive medicine　　L iver3 Z: m1 L7 T" H# J  [

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