干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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刘晓珑　李波) t: c0 M6 I# W& W
　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文
' `* M% k- H3 q6 B! _献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以: j. t1 J) E6 o( N/ x9 W0 i
分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床
- _, d6 D6 @' C9 p. @相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。
2 S. l0 M0 t# Z1 ~' B【关键词】　　干细胞　　再生医学　　肝脏
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, O( o+ P7 X, |7 Z, ~DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU
3 ?2 B3 j: S" A  P1 f0 lX iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,$ H6 Y0 R/ [5 ~* J5 |  Y1 I
610041, P. R. Ch ina. E 2m ail: g x lliu@126. com
+ |- V! k0 {2 r* ~  h! TCorresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn. V$ v$ M- p) e  ~! i  v
【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive5 Y" g/ V3 Q! C; t$ }, ^8 Q: u  y
t reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,! e7 ~* V( N6 K' ]0 i4 O
adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere
4 w2 o! y0 ~# [2 q$ o" ^extensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,1 m- t# G0 D1 w5 ^8 Y! F
i. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell& b0 C; ]' {) G- w* A
fusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the
3 f7 u, I" o, W8 W, n7 D* v% ~' iapp licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further
7 m9 O0 n9 [3 r- ^# F# Y! cstudies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the
, P% Z9 J: K0 u! G4 l1 mliver stem cell t ransp lantat ion." Z3 z# P# Z3 C' |0 ~7 Q
【Key words】　　Stem cell　　Regenerat ive medicine　　L iver
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