干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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  t0 y% }  t/ H刘晓珑　李波9 t$ o4 m& U; ~
　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文
4 h) n* r$ J$ b献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以- v, G7 i4 j2 ?( a" T  R
分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床* w: Y+ `: G4 `2 ^
相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。* y. M. I3 |( q! C4 a$ C
【关键词】　　干细胞　　再生医学　　肝脏7 b  r$ t. `6 N  R0 x
中图分类号: Q 813　R65713　　文献标识码:A0 |9 @5 H$ b! R) c# y- h' c
DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU( I) p8 Y. X! ]0 ~$ W4 y( U$ ]  d# }- r
X iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,; R9 M2 F# [, U, E* h" ?
610041, P. R. Ch ina. E 2m ail: g x lliu@126. com
* z+ s) Z( h4 {' X1 Y' E. S% \# _( p; UCorresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn, g% k& U& e. F- O7 `
【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive2 C& A- z2 u+ s4 Q6 h5 X
t reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,' ^  {$ U5 }8 W0 M. E
adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere
$ S( U+ x1 {7 O) J9 ~extensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,
" y5 S2 {' S/ @+ Mi. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell
! R8 R' L* N6 [6 e! Yfusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the
# \& r1 `. A$ S4 d) y% V. D) y- a) Eapp licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further: U. ?0 A* }; {9 w) A/ A* W
studies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the
( n# e6 D) a  U+ s6 eliver stem cell t ransp lantat ion.
" [- R* `& C8 V7 n$ W. T【Key words】　　Stem cell　　Regenerat ive medicine　　L iver* \, n! B$ a% ?* v( t

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