干细胞移植用于肝再生治疗的相关研究进展

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刘晓珑　李波
) U- R9 D/ P% b4 \, r9 ^' Y+ a6 k　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文
8 t9 f8 j( i; `' ^献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以
# l3 b: X5 h* U3 F8 @分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床9 _$ n- g' U% l  K: d% w
相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。
. ?; r. R9 a9 g8 \1 y  l" L3 N【关键词】　　干细胞　　再生医学　　肝脏' d$ r* p$ e" V
中图分类号: Q 813　R65713　　文献标识码:A0 y# L( ~/ G. _7 R' w
DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU
# l; o+ t5 x0 D4 E! r% ]X iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,
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& G$ M* l: K! u1 eCorresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn
9 m0 z6 Z7 N4 C5 W: W; a( w【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive
6 U1 s6 D! i+ a3 Y1 z$ T% g  S: wt reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,# ~4 [( `# b! b; @
adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere
" Y- j7 X6 d* d; {# qextensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,
- z/ \+ B( C( g+ M# X  ti. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell9 L: Z* G; f5 R( E8 w" d& N
fusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the) Z+ K/ r6 a5 S; u  I' B  t
app licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further2 Q. D; {  T* h/ ~% r4 \. @+ T
studies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the3 G. u. o. ^4 d. \  ^4 ~
liver stem cell t ransp lantat ion.+ y* p2 X& U, f
【Key words】　　Stem cell　　Regenerat ive medicine　　L iver
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