干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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! D- v, G' s  \# c刘晓珑　李波
: j' Q- f$ Q+ k9 a% o　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文- Z1 g9 j* X; l9 Y* ?
献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以$ Q& }. l" A  c8 G* R
分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床
& C: Z6 M' s% L; J3 E2 c  `% b相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。$ W% I- R8 ?9 ^1 i
【关键词】　　干细胞　　再生医学　　肝脏
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DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU
1 F2 B" m* V; w; D! m/ sX iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,& l7 i$ ~$ K# D/ x
610041, P. R. Ch ina. E 2m ail: g x lliu@126. com
0 G) K4 \) b0 d0 Z. n5 k- ^Corresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn
5 @+ m% K5 K* f% q+ S5 r【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive
% T0 d) y+ @0 Ht reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,
  l. {1 @$ Y# N" L$ W7 l; Ladm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere$ ?/ K+ F2 V! C
extensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,
+ Z5 L: U, }4 k3 G+ Hi. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell
# D2 A! `# h8 Y4 Z2 v* A1 efusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the/ V5 B  o/ {! N0 R- q2 V
app licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further
+ W7 C0 k" {( W4 w  b- V6 ustudies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the
8 }* p& v. \' Q+ C6 [, Pliver stem cell t ransp lantat ion.
2 ^3 |0 M- b7 ?9 L, a- w; z【Key words】　　Stem cell　　Regenerat ive medicine　　L iver) k. T/ E9 r2 d% C
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ALLUL

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baixiaodgv

1# guokeyi
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