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- 积分
- 559
- 威望
- 559
- 包包
- 1201
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摘要
9 m2 X, K) l0 |In 2006, it was reported that transgenic expression of merely
0 l, L5 s7 e" Z. Q, o/ |5 ~ ifour defined transcription factors (c-Myc, Klf4, Oct4, and Sox2)
& I9 [5 V* P# u% X' wis sufficient to reprogram somatic cells to a pluripotent state.& r& T; T9 M) D& {) D( ?/ S
The resulting induced pluripotent stem (iPS) cells ignited4 e+ F/ I# B$ {
intense interest in the field of life science for their promising0 F# x# p; t9 ^$ ~* B$ p$ f, M3 {
applications in basic biology, drug development, and transplan-) G: E; ]3 O, Q2 p
tation. However, the underlying problems of iPS cells seem to$ f5 d6 T' F4 ?2 Y
be ignored. This review shed light on the problems pertaining
9 Y' j) V! Z: _3 C- NiPS cells, including the elusive origin, risk of tumorgenesis, and4 B, J; K9 w& F; @* T
its relationship with natural selection. 2010 IUBMB |
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