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- 积分
- 559
- 威望
- 559
- 包包
- 1201
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摘要 [* }! R: Z2 G) \
In 2006, it was reported that transgenic expression of merely; \. \" F8 S4 F& _2 T
four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2)
5 |0 _$ L3 f$ pis sufficient to reprogram somatic cells to a pluripotent state.
/ M: f: Q3 ?3 Z v9 S, KThe resulting induced pluripotent stem (iPS) cells ignited; u- x3 O2 ?. F3 r) v
intense interest in the field of life science for their promising/ X# W' w4 C* C E
applications in basic biology, drug development, and transplan-
. P0 b/ C; r. n' ^7 i) Otation. However, the underlying problems of iPS cells seem to
) O7 J% _: t6 W( A: U( Jbe ignored. This review shed light on the problems pertaining9 l/ c0 p3 P) t) |5 h
iPS cells, including the elusive origin, risk of tumorgenesis, and& c: x5 i; W: b+ q x1 x2 u' Y
its relationship with natural selection. 2010 IUBMB |
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