|
 
- 积分
- 559
- 威望
- 559
- 包包
- 1201
|
摘要3 y: s1 P* h" d/ ]/ k2 {
In 2006, it was reported that transgenic expression of merely
9 I& p+ e9 e: q5 O* Ufour defined transcription factors (c-Myc, Klf4, Oct4, and Sox2)
2 {4 S4 @" C; C; z# iis sufficient to reprogram somatic cells to a pluripotent state.
, [% Z" P* }7 a& C4 uThe resulting induced pluripotent stem (iPS) cells ignited
- T' |1 L1 |) C( xintense interest in the field of life science for their promising
$ O9 u. K/ q7 W2 N+ n8 ]applications in basic biology, drug development, and transplan-
: a9 A. `! v' s3 v3 Z, V6 _tation. However, the underlying problems of iPS cells seem to
. S9 g* q, F! I* ]( sbe ignored. This review shed light on the problems pertaining
* Z" x+ Y1 ^9 d/ Q3 d" ~iPS cells, including the elusive origin, risk of tumorgenesis, and
: ~7 ?' P7 x$ \1 R2 dits relationship with natural selection. 2010 IUBMB |
|
发表于 2010-7-10 13:10
发表于 2010-7-10 17:58
