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A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer 2 w0 Q4 h* e3 b6 V; }
- e0 I2 A1 Q" e! \. i4 z) p) B, @Roberta Pang1, 2, Wai Lun Law3, Andrew C.Y. Chu2, Jensen T. Poon3, Colin S.C. Lam1, Ariel K.M. Chow2, Lui Ng1, Leonard W.H. Cheung1, Xiao R. Lan1, Hui Y. Lan1, Victoria P.Y. Tan1, Thomas C. Yau1, Ronnie T. Poon2, 3 and Benjamin C.Y. Wong1, 2, , 0 D/ M) X$ I+ E# i- K+ ]2 C
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1 Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
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# B( g% g! C) u0 _0 L2 p2 Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, A/ W5 W' ^2 ]/ v- V( C9 b
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3 Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR4 W/ o' B x4 a/ G0 n8 c3 a4 U' F
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Received 11 November 2009; revised 18 February 2010; accepted 9 April 2010. Published: June 3, 2010. Available online 3 June 2010. " ^4 v+ L" W- U7 n
( l3 U: Z2 ?+ p8 y A% i) ?' v1 @& aSummary3 c$ j. ? B1 u2 }6 n. p# z# ~
Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26+ cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26+ cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26+ cells, but not CD26− cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26+ cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy. |
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发表于 2010-7-20 14:41
发表于 2010-7-20 16:12
