《细胞-干细胞》[Cell Stem Cell]2010年9月3日出版pdf全文

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3 September, 2010 Volume 7, Issue 3
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9 n* t0 Z8 b7 [( z. k$ EEditors' Notes
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Previews3 x, G; P8 \+ q* s  o
Cancer Cell of Origin: Spotlight on Luminal Progenitors
- ^  x4 Y2 Q6 [( WChristine L. Chaffer, Robert A. Weinberg6 R  t/ c+ B. q; y1 c( z
Microarraying for Mechanosensivitity  L$ k3 x/ Z5 x& a/ \0 L
David V. Schaffer
; V( F/ s7 {9 A# r0 h" }The STATs on Naive iPSC Reprogramming
5 M1 l" j6 M+ T- K6 x1 tJacob H. Hanna
* }! k) _# \( ~( a0 FHypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword
/ f$ k& X, n8 M' j& t' X; sPatrick J. Pollard, Kamil R. Kranc
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' j5 }7 W4 }, w; |' @' zBrief Report- G7 ~3 ]* E3 N$ I, I
Tumor-Initiating Cells Are Rare in Many Human Tumors+ u: A3 D$ j2 @+ e( z1 n6 L9 }
Kota Ishizawa, Zeshaan A. Rasheed, Robert Karisch, Qiuju Wang, Jeanne Kowalski, Erica Susky, Keira Pereira, Christina Karamboulas, Nadeem Moghal, N.V. Rajeshkumar, Manuel Hidalgo, Ming Tsao, Laurie Ailles, Thomas K. Waddell, Anirban Maitra, Benjamin G. Neel, William Matsui
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Forum
9 h8 A. t! o* k% `2 V2 V% UThe Orphan Drug Act and the Development of Stem Cell-Based Products for Rare Diseases
& p4 }1 _2 t6 y7 c* [" [! [Scott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté- x: u' B1 `( f8 t

+ l7 o2 D5 {9 K. w7 cReviews
4 t& I/ c! }4 ePolycomb Group Proteins Set the Stage for Early Lineage Commitment
# C) t6 g# a! \Lauren E. Surface, Seraphim R. Thornton, Laurie A. Boyer7 \0 Z! f! H4 d" F- G! {
Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
; M# N5 V% E2 L0 W0 J- b6 uMartin Sauvageau, Guy Sauvageau
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; Y: C5 D9 b6 S! W5 `5 L$ oISSCR: President's Note
  o& ?" `- r: G% p) I1 sToward a Knowledge of Causes" m2 S5 X! Y5 }* }# `* d" r% B" `
Elaine Fuchs  C- |7 w" E+ ]  L; M1 T  @8 u! f

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Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
3 L  P' G3 K- ^. r2 {7 B, iJian Yang, Anouk L. van Oosten, Thorold W. Theunissen, Ge Guo, Jose C.R. Silva, Austin Smith3 e2 ^. t6 m* |/ Y  i
Female Human iPSCs Retain an Inactive X Chromosome0 }! J/ ?- ^; {# x; c5 W  x' k7 T" A
Jason Tchieu, Edward Kuoy, Mark H. Chin, Hung Trinh, Michaela Patterson, Sean P. Sherman, Otaren Aimiuwu, Anne Lindgren, Shahrad Hakimian, Jerome A. Zack, Amander T. Clark, April D. Pyle, William E. Lowry, Kathrin Plath& L7 e- h+ [6 ^; l" \# K
Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells8 Y( q5 ^4 I& Q, r6 h7 r
Keriayn N. Smith, Amar M. Singh, Stephen Dalton  E' B1 M, L, N3 F/ R! j
Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation
6 U' c% g, x# Q  ]( u$ WMirza Peljto, Jeremy S. Dasen, Esteban O. Mazzoni, Thomas M. Jessell, Hynek Wichterle
$ I/ d& u; j9 M: JRegulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling( \1 R# B5 S  R& r# U$ V
Sacri R. Ferron, Natividad Pozo, Ariadna Laguna, Sergi Aranda, Eva Porlan, Mireia Moreno, Cristina Fillat, Susana de la Luna, Pilar Sánchez, María L. Arbonés, Isabel Fariñas% |. F  U5 N7 {, b' y: d
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
8 y* t$ {5 Y' cTugba Simsek, Fatih Kocabas, Junke Zheng, Ralph J. DeBerardinis, Ahmed I. Mahmoud, Eric N. Olson, Jay W. Schneider, Cheng Cheng Zhang, Hesham A. Sadek
2 G3 y3 _+ G; zRegulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells( L5 ~7 e2 @. }+ o
Keiyo Takubo, Nobuhito Goda, Wakako Yamada, Hirono Iriuchishima, Eiji Ikeda, Yoshiaki Kubota, Haruko Shima, Randall S. Johnson, Atsushi Hirao, Makoto Suematsu, Toshio Suda$ D# y* |0 R( h
Featured Article
9 x8 d: G9 m+ e- kBRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells9 V( q1 c- m# b) \+ J; m
Gemma Molyneux, Felipe C. Geyer, Fiona-Ann Magnay, Afshan McCarthy, Howard Kendrick, Rachael Natrajan, Alan MacKay, Anita Grigoriadis, Andrew Tutt, Alan Ashworth, Jorge S. Reis-Filho, Matthew J. Smalley5 J0 z- X( |; X, d) Z
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