《细胞-干细胞》[Cell Stem Cell]2010年9月3日出版pdf全文

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: S3 Q+ ?6 v  c# s3 September, 2010 Volume 7, Issue 34 M0 p' I/ o8 I; }* `3 H$ U

% @& W4 s( ~0 d" R1 t3 G0 Z7 UEditors' Notes7 l3 Q6 C6 C$ a' E

  {  r: i* C7 I, e) N3 d8 V8 ePreviews
2 V. {5 c6 X) T$ D  l! Z" ECancer Cell of Origin: Spotlight on Luminal Progenitors
5 D' \! @( |, }) ]( m: i' [Christine L. Chaffer, Robert A. Weinberg
2 f/ m: `4 E  ?1 c6 R# AMicroarraying for Mechanosensivitity
- x1 }8 ^( a/ \" c  v, ^# wDavid V. Schaffer, W4 F! ^1 n' M* H7 P$ |
The STATs on Naive iPSC Reprogramming8 w, q  I# F. K. h) \
Jacob H. Hanna! v/ b8 c+ U$ Z# i8 r/ L2 Q
Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword7 e/ }6 v) K1 L
Patrick J. Pollard, Kamil R. Kranc/ T7 x; k" L* @% y, w3 N* S1 K/ u

$ J) ?8 q' F7 N; VBrief Report
; g# P9 S+ {! S5 g" V+ ?Tumor-Initiating Cells Are Rare in Many Human Tumors: R+ |$ b$ S# K
Kota Ishizawa, Zeshaan A. Rasheed, Robert Karisch, Qiuju Wang, Jeanne Kowalski, Erica Susky, Keira Pereira, Christina Karamboulas, Nadeem Moghal, N.V. Rajeshkumar, Manuel Hidalgo, Ming Tsao, Laurie Ailles, Thomas K. Waddell, Anirban Maitra, Benjamin G. Neel, William Matsui
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Forum, r" ?  [1 [* N  z3 S
The Orphan Drug Act and the Development of Stem Cell-Based Products for Rare Diseases
. h% m* e' p% Z( N$ h+ p  [3 G$ PScott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté
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- p8 V  R7 H2 G5 R8 Y  tReviews% K4 |7 ?& F. Z; K
Polycomb Group Proteins Set the Stage for Early Lineage Commitment
. W; M$ d- R* y7 j% FLauren E. Surface, Seraphim R. Thornton, Laurie A. Boyer
+ Q; x/ s; H$ `/ N2 Y2 \8 Q# w# e- `  uPolycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer" k1 t9 Q, Z( Z8 ]) @
Martin Sauvageau, Guy Sauvageau
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ISSCR: President's Note
+ s( l+ V7 D# pToward a Knowledge of Causes
* P, k# V' }$ K8 u& JElaine Fuchs- i% [# }+ c0 p# c- B! U

, H, w# N4 A1 b7 F6 J( ZArticles4 \; D; e7 u1 W7 n; J
Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency* n1 l: R& H# b  d' s$ h
Jian Yang, Anouk L. van Oosten, Thorold W. Theunissen, Ge Guo, Jose C.R. Silva, Austin Smith: H5 W; R" ]4 L
Female Human iPSCs Retain an Inactive X Chromosome
$ q5 g- \7 T0 f! j/ q5 _) MJason Tchieu, Edward Kuoy, Mark H. Chin, Hung Trinh, Michaela Patterson, Sean P. Sherman, Otaren Aimiuwu, Anne Lindgren, Shahrad Hakimian, Jerome A. Zack, Amander T. Clark, April D. Pyle, William E. Lowry, Kathrin Plath
2 K0 T/ v; D- J5 u" OMyc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells
4 |3 m$ G( K+ e3 z9 ?Keriayn N. Smith, Amar M. Singh, Stephen Dalton$ Q& D; n/ `/ }$ Y. S
Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation
2 f! Y0 g9 u6 _; QMirza Peljto, Jeremy S. Dasen, Esteban O. Mazzoni, Thomas M. Jessell, Hynek Wichterle
; q! D7 r& O6 N  C, |+ p3 N* JRegulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling8 |- I' V6 x6 x
Sacri R. Ferron, Natividad Pozo, Ariadna Laguna, Sergi Aranda, Eva Porlan, Mireia Moreno, Cristina Fillat, Susana de la Luna, Pilar Sánchez, María L. Arbonés, Isabel Fariñas. {6 X" b- G* t0 z( s5 h6 @
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche) j9 c% N; x7 w6 x
Tugba Simsek, Fatih Kocabas, Junke Zheng, Ralph J. DeBerardinis, Ahmed I. Mahmoud, Eric N. Olson, Jay W. Schneider, Cheng Cheng Zhang, Hesham A. Sadek8 Q+ Q3 |5 C* ~) {; c! I
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
9 Y4 P8 m3 g( A/ o% c7 VKeiyo Takubo, Nobuhito Goda, Wakako Yamada, Hirono Iriuchishima, Eiji Ikeda, Yoshiaki Kubota, Haruko Shima, Randall S. Johnson, Atsushi Hirao, Makoto Suematsu, Toshio Suda
9 H/ p6 p) C. |" P' t" ZFeatured Article
& _5 d, E8 Y4 `" K: gBRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells( B: y7 m+ z6 N
Gemma Molyneux, Felipe C. Geyer, Fiona-Ann Magnay, Afshan McCarthy, Howard Kendrick, Rachael Natrajan, Alan MacKay, Anita Grigoriadis, Andrew Tutt, Alan Ashworth, Jorge S. Reis-Filho, Matthew J. Smalley: e% |' {9 f; o: s( U2 L  Y* b
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botizhou

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