iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
. I" F& z4 g3 o' E1 X! z" t1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).% H' |9 j1 ^- @. i1 d! v
神经疾病：( o0 m+ M: O. {0 X3 g
2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).* w) X( e1 c2 L5 d8 ~9 _1 V
神经疾病：
+ g0 z4 K8 J+ d) b2 i! J) p3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
# T# {1 a: X0 _( n3 W  o) U神经疾病：) z" l/ k/ L7 e# i. [% b
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
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* {1 O* E" J9 o; A5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).9 C7 i5 M/ K) J
血液疾病：# h9 K) V4 W* T1 t
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
% B9 Q3 r: ~5 Agenomic imprinting disorder：1 _5 C  i3 t. ?: q3 h
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成功观察到疾病细胞表型的：
" V5 m7 U  e: p3 M9 v. E: [$ M) R7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).; M1 S% Z2 d6 W# K/ H
神经疾病：
$ a. F$ M, {5 }: L, K" u: z8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).; i: c& H4 @9 `4 c6 B! h
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9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).+ q) n  v/ V* o! E
血液疾病：4 H, J3 ]% L& f0 }& ]) Q
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).* p( m3 G& F$ o( I/ c0 r5 L0 p
肝脏疾病：. d# L) o2 Y  ]
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
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12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010)." M* O* i7 u$ M# o, e
肝脏疾病：
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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0 j- a% q+ |& H7 x. O& O外加一篇：
+ k' b! e1 A4 h. u, V13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
, ]7 L5 C" Z3 O$ L1 D* \2 kLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau   L: n' x' _& r4 ~# m# I; P
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# L! t4 s! r8 \% j5 T: u14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability) k8 x4 N% r. [- v; ]" V3 Y3 _0 d# S
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。0 B5 k, _4 J2 ?9 B0 x* O8 P
原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们