iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：3 x; \. c9 P/ l( p$ b" {
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
9 ^% ]9 _% J% z  M. A7 j" w2 d" @神经疾病：
. z. a) f4 d" F$ ]5 q4 x2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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+ i& `* c  p% S( w4 P( {  C6 F+ \3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).$ x; I0 f! ^: {' o5 X% W* ^6 M' ~
神经疾病：5 C9 p! z4 _0 ^8 G
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
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5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).9 |2 ]- E$ ]/ M) C0 n& L5 g
血液疾病：7 l( ?, S: [5 ~! ]
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
! y) |4 {" u% n* d) T, \1 f  h  E' O/ zgenomic imprinting disorder：) Y  b+ s4 }& ~! Y; ^" d
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6 D' a0 w* ], ^/ V# W2 e9 v( c% w成功观察到疾病细胞表型的：
( S. ~: T  x. n- F# t7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).+ u) Y2 |( K, ]# r. i8 W
神经疾病：( c- r# \4 S' s% M' z5 h8 Z& o$ w8 m# D
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009)." X; j* @2 j& o4 s; ~% M
神经疾病：
" ~9 }2 w( n, e0 C1 n- W+ e3 \9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009)./ @& ?# G' K, N2 I+ i
血液疾病：
$ i' k* c1 R: c10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
  [9 Z) ^- d$ t9 O肝脏疾病：
2 y% A, f* z' H11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010)., z1 X$ l2 ~/ [" K5 L
心脏疾病：1 U2 @0 L# ]0 U0 t
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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外加一篇：' f9 v5 D# q& u, u4 ^- j8 j6 ^8 V
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
9 {4 X9 H  C" T1 `2 j/ g. I3 e3 QLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
* ?! L- D4 x3 D: sFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
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乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们