iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：7 p2 a8 ~4 A/ p: {' V1 z
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
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+ r- Y2 q# C. |- H; ?: l2 B) I2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
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( b0 d$ G& |2 M9 n+ R: ~5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).% i: f" L, m1 a/ Q; l* W6 `. f$ `; x
血液疾病：
" L7 z' w' G7 a' G! T4 V- k6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.9 b, u5 n7 M  u5 A$ p8 ~5 _! Z
genomic imprinting disorder：1 R4 v+ `/ d; j6 T

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成功观察到疾病细胞表型的：; D  y  m0 {7 r" g5 X
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
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8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).7 N, F& Z/ c* b5 v* w# p1 v
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9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009)." S# R# U" R2 S" n8 |
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10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
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% B4 ?! i) E% f6 b- q! |+ X11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).5 K  N0 n0 A$ x% o; X+ r: ]
心脏疾病：7 F- R: A3 E' F, |
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau 1 |) C* X5 |; b6 v

7 i  l. M1 n/ n( g/ ^7 b. ?. Y: k外加一篇：1 ^/ A1 Y3 W# O. E; n" A
13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
  g" U; \; i4 @! V3 M# D% YLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau   Y$ @1 t9 y$ B

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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
5 {2 c) ~! a' dFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
0 y3 J1 z7 _& L7 L1 Q; U- w7 j5 s原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们