iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：: H% Y8 T, g" F
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).: L" d7 o8 |, u5 X
神经疾病：
: _( {; |, o0 P0 [2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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9 q3 y1 \9 G; n$ G) _; R+ s3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).+ B4 k! j  R5 n2 w# H4 {2 R# K
神经疾病：% ]5 y2 E& Q; F% X" ^" j4 l
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
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5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
" A% [/ p# f3 W. z5 F0 Y血液疾病：0 p  r$ J7 s/ Y9 G' ?0 C5 l
6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.# r/ r: A( N. ?: h/ {
genomic imprinting disorder：" Z: w2 Y- T% q2 f1 _$ n. j

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成功观察到疾病细胞表型的：
+ T+ y7 [. V; f  w( x) Z+ l7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
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( X7 u0 c, A, Z) k* Y# k8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
2 _6 H8 i6 e! L1 z; @. h: x" E神经疾病：
$ _8 q0 P0 P* J& b9 k+ x9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).4 d! p+ p1 Z% ?! a1 e! t
血液疾病：& V' m2 k4 w2 \5 l
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
3 P) @- s6 s" o; [- Y$ Y4 n6 I肝脏疾病：+ N: Z* u4 S7 `1 o
11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
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12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).& D8 w6 O- y3 L" ?' A) S/ Y* c
肝脏疾病：3 t2 c8 w& j2 I0 B& s

( S# P+ g9 n! K1 ^' S, {望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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外加一篇：
3 G' U& W& D! D7 X13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome" D0 h% ?7 N7 S4 ~/ o
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau " w+ _3 {9 m5 N" I3 r" h- ~% `
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
* V# O4 x, t; h* y% QFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
5 p, A# p/ ~& e& Z. y# X* ^2 |5 h. f1 R原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们