iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：& b" _3 I; ]( Q! y$ l
1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).% ?: _# c9 q- o* B+ W/ e4 f/ N$ N
神经疾病：
3 V. O% T* ?6 }( q4 _2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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8 e1 Z1 E, l1 N. B3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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7 a4 Y( ^% P6 X* T4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).- y$ n2 r3 }4 _# f" ^4 h
糖尿病：
: q: V1 Q+ A' h& t5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).  E, @7 y& ^/ t( `
血液疾病：
. Y4 f4 w( n3 F& h+ e9 f6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
! H- H: L7 Z. `' x; `genomic imprinting disorder：
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3 U- m# `& r" j+ J8 v* M成功观察到疾病细胞表型的：0 z6 @; ]2 D" G
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).2 m: d! K& F& v( @( M0 W
神经疾病：( f! J5 j# ~" X) [. G. l
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).  Q0 D0 W4 {2 d4 l. [$ _
神经疾病：
. K- a0 z( d/ [, y9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
9 [$ L/ u8 r8 R) w血液疾病：' e* h2 e0 y; U7 r" p  \
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
$ l; s7 e6 o, A- d) Y7 a( s肝脏疾病：
  m- s" ~: @+ t( a8 i$ N. R+ c11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
' a0 p& s3 Z- B' m心脏疾病：4 j4 E1 [- |9 D) h( C# o
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).3 b: L% r+ D+ T! y1 ?( W
肝脏疾病：
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望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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% j+ H5 b; F% ?( t+ X4 J9 A外加一篇：
. b, N) h- `/ v$ k13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome9 E  w: K3 B! p8 [8 T
LEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau + }/ c% D5 l5 p: t8 Q
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability
+ ?/ V5 ?8 _8 w0 q) FFriedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
1 }% N- i+ Y& Q) @* K原文：

乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们