iPS与疾病模型的12篇文章！

linlicau

分化但未观察到疾病表型的：
  Q; z' C/ c5 M' G! h1.        Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
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2.        Park, I.-H. et al. Disease-Specific Induced Pluripotent Stem Cells. Cell 134, 877-886 (2008).
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3.        Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
3 w' J4 f; j( Y0 |0 b8 g8 J神经疾病：% d# @  d2 Q# D; P: C' j
4.        Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
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  \. C) ?+ b) @/ g* `, N5.        Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).: x! U! l* L9 z" W
血液疾病：
8 m3 \: q- [& q, |' Y8 l9 d6.     Yang, J. et al. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry.
: v9 \  i! C+ u4 agenomic imprinting disorder：
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成功观察到疾病细胞表型的：6 K! f' v$ O" ]% o
7.        Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).3 u' }2 Y  {. x, F: y
神经疾病：, c; C6 O" H% \9 ?' T& ?% q
8.        Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).9 y' Y5 @6 {8 K6 X$ n0 X8 W, S4 M  k
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9.        Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009)./ Z8 i: V. e! D% L* v+ [: `! Y
血液疾病：# w7 H1 \$ s; m0 n: h2 b8 g6 j! D' C
10.        Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
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11.        Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).2 Y) s2 H3 N) S4 _8 N, c$ F4 G
心脏疾病：+ N2 Y: V0 _3 e9 `5 I
12.        Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010).
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& p% }- F# M7 r/ z+ i) n望细胞海洋多加威望和包包啊~

linlicau

回复 1# linlicau
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) Q7 d& i/ G' p& K9 h7 c) V# v8 O外加一篇：
; [0 j+ m% h" B13 Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
5 V- J6 U9 Q* N/ Q+ mLEOPARD syndrome（豹斑综合征:遗传性皮肤病合并肥厚性心脏病。最后重现疾病分化的是心肌细胞，）：

linlicau

回复 2# linlicau
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14.(最新Cell Stem Cell) Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA,TTC Triplet Repeat Instability. b. [: U/ e0 E
Friedreich’s Ataxia 弗里德希氏共济失调 在iPSC中发现(GAA)n 延长，与疾病模型一致。并且验证了部分机理。
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乳杆菌

谢谢~~

hai1986

谢谢总结

marrowstem

极好资料，谢谢分享。

大笨鸟

谢谢分享

jane1lee

谢谢分享，很好，很强大！！！

艾心痕

谢谢，感激涕零！

苏眉1989

真的找到了。谢谢你们