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肝细胞 hepatocytes7 _& Y a* I( ~8 x4 m- ?$ J
1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
- W/ n2 m1 d `, y' J- V2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010). 9 w3 ]( a5 a: k& c
3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010).
/ v8 m; L! v1 u8 P4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010).
5 b: E* V& g6 a6 F, m5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009).6 n& [+ @2 ]: b2 u3 m
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神经细胞" a' Z4 P# [. D$ u2 Y- C [
neural crest precusors
9 M# l4 m' L1 ~, M5 R' \8 S* o: L* q6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
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neuroepithelial cell
4 z1 i' B, c" p7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010) * O V+ |1 X3 ]4 p
; K7 y/ s5 Z5 D% j/ }motor neurons【包括文献7】
7 l& e& p% G# f4 q8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
' g" T5 f% F3 |$ i9 c2 j9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009). * ?9 d0 {) R" E' m9 I
10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009).
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dopaminergic neurons of the midbrain 【包括文献10】# j1 |9 M1 y ~4 Z$ h
11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009).
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8 J' x O _/ g& E8 ]4 d k" Lglia 【包括文献7,8】
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视网膜细胞- S$ J; v9 {1 f" X$ L
Retinal Pigmented Epithelium* Z, E% |0 f. b& Q
12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).
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- K) b/ J; t3 p" e3 t2 Iretinal cells
% N# E0 h' F1 A9 E4 N13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).
" b8 g& @9 ?7 ^' v" m' k5 S$ ?14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).
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心肌细胞 cardiomyocytes* C* @9 Q8 Y G r! e' _+ ]
15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).
# d# _4 W* }$ x" ]; n16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).) N& l L, g' {# V, Z
17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).
% ?: ^ C# K* [# H m% S( c+ t [18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009).8 ^/ M3 e Z9 w! N8 u g
& r; p% U9 u# Z5 ?- o$ Z$ x+ T/ X血管和血液相关细胞8 G. N* r M: i7 [" r
haematopoietic progenitors8 p& y- Y4 q: n* _& `" i" K
19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
- V+ i( [( l/ r20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
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. }& |; _( d7 V$ ^$ S$ sblood cells' ?; I" h9 x' z: D2 w
21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009).' t2 O+ d7 a! y- Z) K$ n
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vascular endothelial cells【包括文献21】
8 Q" Q' ^( q* }5 |1 p1 n22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).# x7 k' a/ ]0 @6 {3 }0 e/ T- p( u( r
23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009).
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' H9 `6 J" |! \* S+ M胰岛素产生细胞 insulin-producing cells9 J' F! A- Q( {/ s; n# b% }' S
24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).; k7 \6 K, a8 q4 a! y& G3 ] w6 C
25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).
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* \, |" r# s8 ?9 @原生殖细胞 primordial germ cells3 S2 w! V0 i. e: x
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).
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9 y0 c' G6 g4 f3 |2 E' a0 m6 H脂肪细胞 adipocyte
+ c; i* D C% I- l27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009).
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