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1 Rashid, S.T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. The Journal of Clinical Investigation 120, 3127-3136 (2010).
+ }$ m( }" c8 d2 Ghodsizadeh, A. et al. Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6, 622-632 (2010). & Q- ?1 `5 \6 b9 a/ N$ _5 m
3 Sullivan, G.J. et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 51, 329-335 (2010)." A/ B5 |+ ]& r( P8 l" D. ^" ]$ V( i- c
4 Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells. Hepatology 51, 297-305 (2010).
) c; D* [& C% m7 _5 Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res 19, 1233-1242 (2009).
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神经细胞/ h3 v; }$ r. W+ |( [
neural crest precusors
& M' {% ]6 L* ]) w) Y8 f3 I6 Lee, G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
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neuroepithelial cell3 e' E- T' S2 [" ]- j; `$ [
7 Hu, B.-Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences 107, 4335-4340 (2010)
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_2 }7 n8 C) d" d" |motor neurons【包括文献7】3 o# a7 I/ @+ l. t4 V; Y% _
8 Dimos, J.T. et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 321, 1218-1221 (2008).
* j; Y3 g0 x" F- w5 P6 R9 Ebert, A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
" o- R6 X% \% h1 n/ {6 F10 Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotech 27, 275-280 (2009).
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5 S+ p. G: ^: X/ C7 R, Y+ tdopaminergic neurons of the midbrain 【包括文献10】
9 ~8 G) O. ] H5 B" t% e. Z11 Soldner, F. et al. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors. Cell 136, 964-977 (2009). : h) U- P' K$ I$ T. E! X
- p. ]; ~ U& y- @glia 【包括文献7,8】! ?+ C5 L9 @3 ^4 n& b$ f9 A
4 m% O4 a; L) Y1 v$ |视网膜细胞
& `8 J1 t# y8 _7 ?# QRetinal Pigmented Epithelium
! R+ |' x- E- a( }* d12 Buchholz, D.E. et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells 27, 2427-2434 (2009).5 Y# B* T2 t7 @* p8 i( Q+ Y
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retinal cells# L3 u ^4 Y% ?5 a' m3 l6 G0 P
13 Osakada, F. et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122, 3169-3179 (2009).
. k% J, }" }" f14 Meyer, J.S. et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proceedings of the National Academy of Sciences 106, 16698-16703 (2009).% h0 q5 I$ C. X3 ]5 U2 T
# t7 i, r( e$ ~! a心肌细胞 cardiomyocytes, [+ X" _6 x8 N" I8 j: Y
15 Moretti, A. et al. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New England Journal of Medicine 363, 1397-1409 (2010).# G: ^% r- b( v, ^+ o/ b* {
16 Carvajal-Vergara, X. et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812 (2010).: C/ |. _/ [2 A4 O" ]1 l
17 Zhang, J. et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circ Res 104, e30-41 (2009).. T$ I4 {, J4 J9 y4 n$ P. \+ J
18 Zwi, L. et al. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells. Circulation 120, 1513-1523 (2009).
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4 z, l7 D% M) ~! E血管和血液相关细胞# u6 x; J2 y6 F% u6 I6 F
haematopoietic progenitors
. D; ^" c) W* o6 p* S- d O8 |19 Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).6 r. p. ]' ]$ R# p0 z$ n4 y
20 Raya, A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).6 D5 |. v9 {, y' K3 u
; R( E9 D- }6 o$ u& Oblood cells
( w5 a" O! H6 X4 m) }& L0 E21 Choi, K.-D. et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 27, 559-567 (2009).% `0 L1 h& J9 @7 q: [" F; D
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vascular endothelial cells【包括文献21】! R' }$ w- m7 L& D( b
22 Feng, Q. et al. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence. Stem Cells 28, 704-712 (2010).9 C2 F# m6 i2 @
23 Taura, D. et al. Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells--Brief Report. Arterioscler Thromb Vasc Biol 29, 1100-1103 (2009).
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; ^. J7 L1 _4 p4 u' s9 y胰岛素产生细胞 insulin-producing cells6 \" S2 R# ] |
24 Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106, 15768-15773 (2009).
5 \: @0 o2 @" T# d1 |# c1 p25 Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19, 429-438 (2009).
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+ X$ k2 o$ t) Z+ v- _原生殖细胞 primordial germ cells, u; c0 B0 s3 F' B5 w* p2 G
26 Park, T.S. et al. Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells. Stem Cells 27, 783-795 (2009).
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" Z9 U- p* P! g/ O" z. g脂肪细胞 adipocyte
* y2 r4 `6 a, D- K27 Taura, D. et al. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters 583, 1029-1033 (2009).; s; f& V2 @7 ^
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