Cell stem cell：美科学家发现正常细胞转化为前列腺癌细胞的机制（个人翻译）

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干细胞在动物中的进化。在低等动物体细胞存在近乎全能的干细胞，同时基本找不到癌变的例子。它们组织结构简单，生长到一定阶段可以出芽或一分为二。而到了高等动物，体细胞干细胞呈现多能或专能，同时癌变现象很多。

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这话说得很对，低等的水螅和涡虫都有成体的全能干细胞，能分化为各种类型的分化细胞，而且其体内似乎没有发现癌变的例子。/ g# v( @* h; Y  W8 w4 Z

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Nature. 2001 Nov 1;414(6859):105-11.# h+ e% B2 W, Y* [" V; l

6 H% G) D# U- rStem cells, cancer, and cancer stem cells.
: x, q. I  f4 \6 VReya T, Morrison SJ, Clarke MF, Weissman IL.. h" Y& R  g7 m$ K: q5 {

5 d3 ~, C: C' }9 f9 H4 hDepartments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA. irv@stanford.edu
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" X5 P* a1 t9 ^Abstract
. H/ J. r7 w6 s' |' u& j0 |, TStem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' - rare cells with indefinite potential for self-renewal that drive tumorigenesis.. [3 b$ J1 V  |0 {% \

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7 W% I" M+ u6 ?* n$ _% E这篇Nature文章虽然老了一些，但就干细胞、癌细胞以及癌症干细胞之间的关系做了较为详细的解析，感兴趣的可以下砸附件看看，接着再讨论，呵呵0 W' z2 f4 M: H  E( {/ n- ]* T

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