文献里Rb基础知识介绍的不明白之处

glasshour

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8 j7 y* a* F$ P' L7 u! `Rb family members bind to E2F/ W9 T5 m' ^/ G4 C1 u/ s
transcription factors, which function as heterodimers0 M) |2 y9 F; N  W' Z
with DP transcription factors. Mammalian E2F family
" m1 Q; R% a0 ?members function either as transcriptional activators or  l- U4 ^  |3 H, C4 p
as repressors. 8 \/ O' z+ E8 [2 P
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Mammalian Rb family members bind
& o+ I% e- x$ n9 Bto ‘repressor E2F’ proteins and actively repress the
8 J  E4 o; t1 i* X: K: U3 D+ xtranscription of E2F-responsive genes during G0 and
4 ~7 ^7 N1 s2 K1 qG1 phases by recruiting repressive nucleosome-remodelling
6 q$ C4 M4 l. ~" m, w0 q# dcomplexes and histone-modifying enzymes to
6 K6 n9 o/ ]: w' h9 I  Y3 K1 Xpromoters.
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: [) q4 G) D- nRb also binds and inhibits ‘activator E2F’) s8 }7 b4 z; R7 ?8 ^! P
proteins during G1 phase. Phosphorylation of Rb family
( C/ h7 W# B# |! d7 E# amembers in mid-to-late G1 phase by cyclin D–CDK4/- D% L+ W4 N% x& h( X
CDK6 causes the release of both repressor and activator" R- `( d" |* l8 N. r
E2F proteins, which abolishes the repression and allows
' G) j& }8 a5 U6 q4 D0 Mthe activator E2Fs to transcribe S-phase genes.
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/ a9 r- a$ d- g+ D9 Y# e1 R8 I) w我想问的是这段文字里面的repressor E2F 和activator E2F作用上有什么区别吗？+ Y+ N  t/ L6 W$ j5 i# q& a$ }
不都是与Rb结合在一起就抑制基因吗？9 u3 v* t$ Z( U5 J) W/ I
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谢谢了！傻瓜问题！
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- E. [8 C( h. @- L& k7 U看起来是一个意思的哦~~只是在不同的阶段。。。。这种思路很奇怪。。

glasshour

完了，发现问题问得太傻了
% b/ O/ T# T( i那个也不能自己删帖子。。。囧了。。。

glasshour

完了，还不能编辑了/ _+ [. E- Q' f5 n: k
那个上文的最后一句
# t. l) ?: P6 ePhosphorylation of Rb family
$ Q* M/ x3 G8 K9 S% Imembers in mid-to-late G1 phase by cyclin D–CDK4/
/ C, F( a8 T$ @1 I* _- a$ ECDK6 causes the release of both repressor and activator6 k4 G# |1 ~% t3 T7 R% q
E2F proteins: J" Y% e2 c. F
把我弄晕了，请高人指点。。。

chips100

感觉跟tet-on和tet-off类似。E2F是个家族，有很多蛋白，结构分为结合区域和功能区域，不同在于 功能区域是激活还是抑制。或者，在不同时期，功能区域被调节，比如磷酸化啥的