一个癌细胞会形成肿瘤吗？

sunsong7

肿瘤细胞是单克隆性的，即一个肿瘤中的所有瘤细胞均是一个突变的细胞的后代。1 g% W% K% R7 C2 Z/ c: f
那么在肿瘤造模时仅仅动物身上植入一个肿瘤细胞能否形成肿瘤？
( \- S# W3 v) k' \换句话，如果一个体细胞发生突变直接成为癌细胞如何实现免疫逃逸？7 @2 M( ~5 V* ^0 [: K) ]. @+ p4 P

sunsong7

贴出摘要：Efficient tumour formation by single human melanoma cells ElsaQuintana15 g# \' m. c6 b. _
*,Mark Shackleton1 *,Michael S. Sabel 2 ,Douglas R. Fullen3 ,TimothyM. Johnson4 &Sean J.Morrison19 E" H# B9 E: f3 P$ u& T: E* T
A fundamental question in cancer biology is whether cells with tumorigenic potential are common or rare within human cancers. Studies on diverse cancers, including melanoma, have indicated that only rare human cancer cells (0.1–0.0001%) formtumourswhen transplanted into non-obese diabetic/severe combined immunodeficiency (NOD/SCID)mice.However, the extent to which NOD/SCID mice underestimate the frequency of tumorigenic human cancer cells has been uncertain. Here we show that modified xenotransplantation assay conditions, including the use of more highly immunocompromised NOD/SCID interleukin-2 receptor gamma chain null (Il2rg2/2) mice, can increase the detection of tumorigenic melanoma cells by several orders of magnitude. In limiting dilution assays, approximately 25% of unselected melanoma cells from 12 different patients, including cells from primary and metastatic melanomas obtained directly from patients, formed tumours under these more permissive conditions. In single-cell transplants, an average of 27% of unselected melanoma cells from four different patients formed tumours.Modifications to xenotransplantation assays can therefore dramatically increase the detectable frequency of tumorigenic cells,  emonstrating that they are common in some human cancers. # @2 ]- }% L. a& L. ?  o