构建造血干细胞源性诱导多能干细胞的抗HIV-1功能巨噬细胞

botizhou

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sunny2829

是不是这篇啊？？有人发过了~~~0 h2 A) W2 h. f9 q9 Q8 x
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诱导的多能干细胞（iPSCs）为艾滋病的治疗提供了希望
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4 \, W9 f. X) X' |. }6 oMol Ther. 2011 Mar;19(3):584-93. Epub 2010 Nov 30.. _/ a0 L2 d2 e

  l) e" s* c5 S6 k$ ^Generation of HIV-1 Resistant and Functional Macrophages From Hematopoietic Stem Cell-derived Induced Pluripotent Stem Cells.! N0 q/ h; q& y) S* c3 I/ R
Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, Kalomoiris S, Nacey C, McGee J, Lindsey M, Fury B, Bauer G, Nolta JA, Anderson JS.
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! \- Q4 W- Q  u, M# tStem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA.
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9 o& p' W, v  s% a, b; UInduced pluripotent stem cells (iPSCs) have radically advanced the field of regenerative medicine by making possible the production of patient-specific pluripotent stem cells from adult individuals. By developing iPSCs to treat HIV, there is the potential for generating a continuous supply of therapeutic cells for transplantation into HIV-infected patients. In this study, we have used human hematopoietic stem cells (HSCs) to generate anti-HIV gene expressing iPSCs for HIV gene therapy. HSCs were dedifferentiated into continuously growing iPSC lines with four reprogramming factors and a combination anti-HIV lentiviral vector containing a CCR5 short hairpin RNA (shRNA) and a human/rhesus chimeric TRIM5α gene. Upon directed differentiation of the anti-HIV iPSCs toward the hematopoietic lineage, a robust quantity of colony-forming CD133(+) HSCs were obtained. These cells were further differentiated into functional end-stage macrophages which displayed a normal phenotypic profile. Upon viral challenge, the anti-HIV iPSC-derived macrophages exhibited strong protection from HIV-1 infection. Here, we demonstrate the ability of iPSCs to develop into HIV-1 resistant immune cells and highlight the potential use of iPSCs for HIV gene and cellular therapies.
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dypnr

干细胞研究还要面向临床

榴榴莲

干细胞研究非常有前途

我心飞翔

免疫细胞疗法治疗肿瘤有效  

sky蓝

嘿嘿  

nauticus

干细胞存储  

tuanzi

我也来顶一下..  

123456zsz

彪悍的人生不需要解释。  

剑啸寒

加油啊！！！！顶哦!!!!!