|
- 积分
- 1184
- 威望
- 1184
- 包包
- 1887
|
2010年Science杂志总结出的10大科技进展中，有关细胞重编程的描述：' R" r. K9 W( ?2 {+ {7 [ @9 @
/ g- X; C; E2 A. ?; P# K' p
Souped-Up Cellular Reprogramming1 h( R) B) `1 F# Z w7 Z9 k
: c4 s5 e% ?0 h: pChanging a cell’s fate by adding extra copies of a few genes has become routine in labs around the world. The technique,
6 A. y' _6 f( m+ Iknown as cellular reprogramming, allows scientists to turn back a cell’s developmental clock, making adult cells behave; t( e+ x+ i6 a' C
like embryonic stem cells (see “Insights of the Decade,” p. 1612). The resulting induced pluripotent stem cells (iPSCs); m$ v( g! ]& \0 d5 i G, m* @
are helping scientists to study a variety of diseases and may someday help to treat patients by supplying them with genetically
( ?: {/ z s/ T! ymatched replacement cells. C7 o4 f# N+ H1 e
This year, scientists found a way to make reprogramming even easier using synthetic RNA molecules. The synthetic RNAs/ j9 [5 V/ [# B: `
are designed to elude the cell’s antiviral defenses, which usually attack foreign RNA. The technique is twice as fast and 100 times6 @1 z7 q: [8 J9 A9 ]9 f( P
as efficient as standard techniques. And because the RNA quickly breaks down, the reprogrammed cells are genetically identical5 u' }9 `# g8 C# o
to the source cells, making them potentially safer for use in therapies.& T1 `! b5 i' K2 h
& f2 |; {! l# }' R5 t
Early evidence suggests that the RNA approach reprograms the cell more thoroughly than other methods do, yielding a% N/ [ v) D3 d5 ~9 T
closer match to embryonic stem cells. The method can also prompt cells to become nonembryonic cell types. By inserting synthetic
. }5 f' O. J6 r" o1 ?4 DRNA into a cell that codes for a key gene in muscle tissue, for example, the researchers could turn both fi broblasts and iPSCs into muscle cells.
5 u$ [) G% l8 a编者对具有调控的RNA分子在细胞重编程中的作用的预言，这么快就实现了，呵呵，说不定就是文章的作者提前透露出来的消息呢。' E; M1 N! u& y. l1 D2 V1 @
8 L$ n7 k/ M" p- o; e, u1 S, ^+ U7 P, G1 h3 _
O% F6 S- C; w' e* K5 `# [. ^
|
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 威望 + 5
包包 + 10
查看全部评分
|
发表于 2011-4-8 09:25
发表于 2011-4-8 21:20
