改变一个氨基酸就可将正常组织细胞变成肿瘤干细胞

sunsong7

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& q% X) C, O* o3 C$ h5 C东加州大学科学家从发育期胎盘中提取正常干细胞，仅仅改变了一个氨基酸就得到了与侵袭性三重阴性乳腺癌相同性质的干细胞...将滋养层干细胞的MAP3K4 与 CBP蛋白灭活将导致超强的攻击性，研究结果发表在五月六日的journal Cell Stem Cell。7 F- s  W2 w6 Z$ r4 n% D! g

7 c( L" F: I" j  s; x% `Normal Tissue Stem Cells Changed into Cancer Stem Cells   by Kathy Jones on  May 08, 2011 at 8:27 PM
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. E6 ^  k& d; E$ LScientists have after isolating normal stem cells that form the developing placenta, given them the same properties of stem cells associated with an aggressive type of breast cancer.- ~% H- L2 `2 N3 E7 n0 _

9 u4 x6 O+ P( j3 F: \The discovery made by scientists at the University of North Carolina at Chapel Hill School of Medicine opens the door for developing novel targeted therapies aimed at triple negative breast cancer.* ~8 M4 M0 T+ x: E
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“We changed only one amino acid in normal tissue stem cells, trophoblast stem cells. While they maintained their self-renewal, these mutant stem cells had properties very similar to what people predict in cancer stem cells: they were highly mobile and highly invasive,” said Gary Johnson, senior study author.
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4 H3 d% Y0 O1 Y. y. v# bThe study led by the first authors, research assistant professor Amy N. Abell, and graduate student Nicole Vincent Jordan, showed that similar to triple-negative breast cancer stem cells, normal tissue stem cells also go through the same program of molecular changes during organ development called epithelial mesenchymal transition, or EMT.$ _" \7 v: V' D

4 R( }/ Z- K. }0 JThis result further suggested that breast cancer cells utilize this tissue stem cell molecular program for tumor metastasis, or cancer spread.
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/ }9 I/ k: a9 t" {The discovery was made using a unique mouse model of tissue stem cell EMT developed in the Johnson laboratory.% V) p4 C' E% ~; W9 F# I

& {0 A& @' V& b" u3 E: \5 EThe study identified two proteins that regulate the expression of specific genes in tissue stem cells during organ development that control normal EMT.6 I- u/ Z) f0 F1 k5 Y4 g6 F; @/ S

: }% N9 M( x, yInactivation of the proteins MAP3K4 and CBP in trophoblast stem cells causes them to become hyperinvasive.
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The study has been published online Friday, May 6, by the journal Cell Stem Cell.
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http://news.bioscholar.com/2011/ ... cer-stem-cells.html
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